DCST1 (DC-STAMP domain containing 1) - Chinchilla Research Resource Database
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Gene: DCST1 (DC-STAMP domain containing 1) Homo sapiens
Analyze
Symbol: DCST1
Name: DC-STAMP domain containing 1
CRRD ID: 1602181
Description: Exhibits ubiquitin protein ligase activity. Involved in negative regulation of type I interferon-mediated signaling pathway and ubiquitin-dependent protein catabolic process. Localizes to plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DC-STAMP domain-containing protein 1; E3 ubiquitin-protein ligase DCST1; FLJ32785; RING-type E3 ubiquitin transferase; RP11-307C12.10
Orthologs:
Mus musculus (house mouse) : Dcst1 (DC-STAMP domain containing 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dcst1 (DC-STAMP domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dcst1 (DC-STAMP domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DCST1 (DC-STAMP domain containing 1)
Canis lupus familiaris (dog) : DCST1 (DC-STAMP domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dcst1 (DC-STAMP domain containing 1)
Sus scrofa (pig) : DCST1 (DC-STAMP domain containing 1)
Chlorocebus sabaeus (African green monkey) : DCST1 (DC-STAMP domain containing 1)
Heterocephalus glaber (naked mole-rat) : Dcst1 (DC-STAMP domain containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1155,033,824 - 155,050,930 (+)EnsemblGRCh38hg38GRCh38
GRCh381155,033,806 - 155,050,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371155,006,256 - 155,023,406 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,272,924 - 153,290,030 (+)NCBINCBI36hg18NCBI36
Celera1128,077,323 - 128,094,429 (+)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1126,368,275 - 126,385,407 (+)NCBIHuRef
CHM1_11156,402,087 - 156,419,230 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:11169400   PMID:12477932   PMID:14702039   PMID:21145461   PMID:23443559   PMID:23535732   PMID:27197753   PMID:27782195   PMID:32556010  


Genomics

Comparative Map Data
DCST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1155,033,824 - 155,050,930 (+)EnsemblGRCh38hg38GRCh38
GRCh381155,033,806 - 155,050,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371155,006,256 - 155,023,406 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,272,924 - 153,290,030 (+)NCBINCBI36hg18NCBI36
Celera1128,077,323 - 128,094,429 (+)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1126,368,275 - 126,385,407 (+)NCBIHuRef
CHM1_11156,402,087 - 156,419,230 (+)NCBICHM1_1
Dcst1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,257,526 - 89,272,560 (-)NCBI
GRCm38389,350,219 - 89,365,253 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,350,219 - 89,365,253 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,154,157 - 89,169,161 (-)NCBIGRCm37mm9NCBIm37
MGSCv36389,436,018 - 89,451,180 (-)NCBImm8
Celera389,385,278 - 89,400,282 (-)NCBICelera
Cytogenetic Map3F1NCBI
Dcst1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02188,672,549 - 188,690,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,672,405 - 188,689,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,082,762 - 208,105,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,537,936 - 181,560,124 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,488,041 - 181,510,230 (-)NCBI
Celera2168,706,913 - 168,724,388 (-)NCBICelera
Cytogenetic Map2q34NCBI
Dcst1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,530,062 - 1,545,139 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,529,926 - 1,545,459 (+)NCBIChiLan1.0ChiLan1.0
DCST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11133,991,485 - 134,008,614 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,991,485 - 134,008,614 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01130,381,851 - 130,398,975 (+)NCBIMhudiblu_PPA_v0panPan3
DCST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl742,428,113 - 42,457,062 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1742,443,787 - 42,457,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dcst1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365804,571,349 - 4,586,459 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,748,214 - 94,768,432 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,748,430 - 94,768,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,530,040 - 103,536,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCST1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl208,779,754 - 8,797,306 (-)Ensembl
ChlSab1.1208,779,692 - 8,797,327 (-)NCBI
Dcst1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248852,451,247 - 2,465,459 (-)NCBI

Position Markers
RH78401  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371155,017,751 - 155,017,874UniSTSGRCh37
Build 361153,284,375 - 153,284,498RGDNCBI36
Celera1128,088,774 - 128,088,897RGD
Cytogenetic Map1q22UniSTS
HuRef1126,379,743 - 126,379,866UniSTS
GeneMap99-GB4 RH Map1557.49UniSTS
NCBI RH Map11213.7UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1453
Count of miRNA genes:610
Interacting mature miRNAs:677
Transcripts:ENST00000295542, ENST00000368419, ENST00000368420, ENST00000392480, ENST00000423025, ENST00000525273
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 4 261 2
Low 519 232 461 207 363 59 2563 87 759 64 870 694 157 1 511 1423
Below cutoff 1901 2694 1220 384 1386 374 1752 2040 2770 290 302 888 14 693 1347 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000295542   ⟹   ENSP00000295542
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1155,033,824 - 155,050,930 (+)Ensembl
RefSeq Acc Id: ENST00000368419   ⟹   ENSP00000357404
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1155,033,970 - 155,049,264 (+)Ensembl
RefSeq Acc Id: ENST00000368420
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1155,033,941 - 155,035,235 (+)Ensembl
RefSeq Acc Id: ENST00000423025   ⟹   ENSP00000387369
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1155,033,829 - 155,050,930 (+)Ensembl
RefSeq Acc Id: ENST00000525273   ⟹   ENSP00000433667
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1155,033,824 - 155,048,139 (+)Ensembl
RefSeq Acc Id: NM_001143687   ⟹   NP_001137159
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381155,033,806 - 155,050,930 (+)NCBI
GRCh371155,006,256 - 155,023,406 (+)NCBI
Celera1128,077,323 - 128,094,429 (+)RGD
HuRef1126,368,275 - 126,385,407 (+)ENTREZGENE
CHM1_11156,402,087 - 156,419,230 (+)NCBI
Sequence:
RefSeq Acc Id: NM_152494   ⟹   NP_689707
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381155,033,824 - 155,050,930 (+)NCBI
GRCh371155,006,256 - 155,023,406 (+)NCBI
Build 361153,272,924 - 153,290,030 (+)NCBI Archive
Celera1128,077,323 - 128,094,429 (+)RGD
HuRef1126,368,275 - 126,385,407 (+)ENTREZGENE
CHM1_11156,402,087 - 156,419,230 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_689707   ⟸   NM_152494
- Peptide Label: isoform 1
- UniProtKB: Q5T197 (UniProtKB/Swiss-Prot),   B4DXB8 (UniProtKB/TrEMBL),   B4DXE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001137159   ⟸   NM_001143687
- Peptide Label: isoform 2
- UniProtKB: Q5T197 (UniProtKB/Swiss-Prot),   B4DXB8 (UniProtKB/TrEMBL),   B4DXE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000387369   ⟸   ENST00000423025
RefSeq Acc Id: ENSP00000295542   ⟸   ENST00000295542
RefSeq Acc Id: ENSP00000433667   ⟸   ENST00000525273
RefSeq Acc Id: ENSP00000357404   ⟸   ENST00000368419
Protein Domains
DC_STAMP   RING-type

Promoters
RGD ID:6857400
Promoter ID:EPDNEW_H1864
Type:initiation region
Name:DCST1_2
Description:DC-STAMP domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1862  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381155,033,829 - 155,033,889EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q21.3-22(chr1:154575689-155292901)x1 copy number loss See cases [RCV000053912] Chr1:154575689..155292901 [GRCh38]
Chr1:154548165..155262692 [GRCh37]
Chr1:152814789..153529316 [NCBI36]
Chr1:1q21.3-22
pathogenic
NM_152494.3(DCST1):c.1252G>A (p.Asp418Asn) single nucleotide variant Malignant melanoma [RCV000059906] Chr1:155045972 [GRCh38]
Chr1:155018448 [GRCh37]
Chr1:153285072 [NCBI36]
Chr1:1q21.3
not provided
NM_152494.3(DCST1):c.75C>T (p.Leu25=) single nucleotide variant Malignant melanoma [RCV000064188] Chr1:155034448 [GRCh38]
Chr1:155006924 [GRCh37]
Chr1:153273548 [NCBI36]
Chr1:1q21.3
not provided
NM_144622.2(DCST2):c.387G>A (p.Leu129=) single nucleotide variant Malignant melanoma [RCV000064187] Chr1:155033146 [GRCh38]
Chr1:155005622 [GRCh37]
Chr1:153272246 [NCBI36]
Chr1:1q21.3
not provided
GRCh38/hg38 1q21.3-22(chr1:155006546-155464263)x3 copy number gain See cases [RCV000140157] Chr1:155006546..155464263 [GRCh38]
Chr1:154979022..155434054 [GRCh37]
Chr1:153245646..153700678 [NCBI36]
Chr1:1q21.3-22
uncertain significance
GRCh38/hg38 1q21.3-23.1(chr1:154566501-157624084)x3 copy number gain See cases [RCV000139902] Chr1:154566501..157624084 [GRCh38]
Chr1:154538977..157593874 [GRCh37]
Chr1:152805601..155860498 [NCBI36]
Chr1:1q21.3-23.1
pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
GRCh37/hg19 1q21.3-23.1(chr1:153751465-156660462)x3 copy number gain not provided [RCV000585385] Chr1:153751465..156660462 [GRCh37]
Chr1:1q21.3-23.1
likely pathogenic
Single allele inversion Pediatric metastatic thyroid tumour [RCV000585807] Chr1:154130985..156843877 [GRCh37]
Chr1:1q21.3-23.1
likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_152494.4(DCST1):c.1086C>T (p.Tyr362=) single nucleotide variant not provided [RCV000971719] Chr1:155043423 [GRCh38]
Chr1:155015899 [GRCh37]
Chr1:1q21.3
benign
NM_152494.4(DCST1):c.596C>T (p.Ala199Val) single nucleotide variant not provided [RCV000972652] Chr1:155041461 [GRCh38]
Chr1:155013937 [GRCh37]
Chr1:1q21.3
benign
NM_152494.4(DCST1):c.473C>T (p.Thr158Ile) single nucleotide variant not provided [RCV000883959] Chr1:155040566 [GRCh38]
Chr1:155013042 [GRCh37]
Chr1:1q21.3
benign
GRCh37/hg19 1q21.3-22(chr1:154898854-155242457)x3 copy number gain not provided [RCV001005143] Chr1:154898854..155242457 [GRCh37]
Chr1:1q21.3-22
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:26539 AgrOrtholog
COSMIC DCST1 COSMIC
Ensembl Genes ENSG00000163357 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000295542 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000357404 UniProtKB/Swiss-Prot
  ENSP00000387369 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000433667 UniProtKB/TrEMBL
Ensembl Transcript ENST00000295542 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000368419 UniProtKB/Swiss-Prot
  ENST00000423025 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000525273 UniProtKB/TrEMBL
GTEx ENSG00000163357 GTEx
HGNC ID HGNC:26539 ENTREZGENE
Human Proteome Map DCST1 Human Proteome Map
InterPro DC_STAMP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:149095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 149095 ENTREZGENE
Pfam DC_STAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142672005 PharmGKB
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.567717 ENTREZGENE
UniProt B4DXB8 ENTREZGENE, UniProtKB/TrEMBL
  B4DXE3 ENTREZGENE, UniProtKB/TrEMBL
  DCST1_HUMAN UniProtKB/Swiss-Prot
  E9PJX3_HUMAN UniProtKB/TrEMBL
  Q5T197 ENTREZGENE
UniProt Secondary B4DXA0 UniProtKB/Swiss-Prot
  E9PHV3 UniProtKB/Swiss-Prot
  Q5T198 UniProtKB/Swiss-Prot
  Q6P1W6 UniProtKB/Swiss-Prot
  Q71S70 UniProtKB/Swiss-Prot
  Q96M70 UniProtKB/Swiss-Prot