Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: ALKBH8 (alkB homolog 8, tRNA methyltransferase) Homo sapiens
Analyze
Symbol: ALKBH8
Name: alkB homolog 8, tRNA methyltransferase
CRRD ID: 1602194
Description: Exhibits several functions, including tRNA (uracil) methyltransferase activity; tRNA binding activity; and zinc ion binding activity. Involved in cellular response to DNA damage stimulus; oxidation-reduction process; and tRNA modification. Localizes to cytosol and nuclear body. Implicated in autosomal recessive non-syndromic intellectual disability; INTERACTS WITH 4,4'-sulfonyldiphenol; 5-fluorouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ABH8; AlkB homologue 8; alkB, alkylation repair homolog 8; alkylated DNA repair protein alkB homolog 8; FLJ38204; MGC10235; MRT71; probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; TRM9; TRMT9; TRMT9A; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; tRNA methyltransferase 9 homolog; tRNA methyltransferase 9 related
Orthologs:
Mus musculus (house mouse) : Alkbh8 (alkB homolog 8, tRNA methyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Alkbh8 (alkB homolog 8, tRNA methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alkbh8 (alkB homolog 8, tRNA methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALKBH8 (alkB homolog 8, tRNA methyltransferase)
Canis lupus familiaris (dog) : ALKBH8 (alkB homolog 8, tRNA methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alkbh8 (alkB homolog 8, tRNA methyltransferase)
Sus scrofa (pig) : ALKBH8 (alkB homolog 8, tRNA methyltransferase)
Chlorocebus sabaeus (African green monkey) : ALKBH8 (alkB homolog 8, tRNA methyltransferase)
Heterocephalus glaber (naked mole-rat) : Alkbh8 (alkB homolog 8, tRNA methyltransferase)
more info ...
Related Pseudogenes: BX284613.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11107,502,726 - 107,565,746 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl11107,502,727 - 107,565,742 (-)EnsemblGRCh38hg38GRCh38
GRCh3811107,502,726 - 107,565,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711107,373,453 - 107,436,468 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611106,880,541 - 106,941,637 (-)NCBINCBI36hg18NCBI36
Celera11104,528,270 - 104,591,267 (-)NCBI
Cytogenetic Map11q22.3NCBI
HuRef11103,298,990 - 103,361,859 (-)NCBIHuRef
CHM1_111107,256,482 - 107,319,496 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ALKBH8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1602194
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.