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Gene: TSEN54 (tRNA splicing endonuclease subunit 54) Homo sapiens
Symbol: TSEN54
Name: tRNA splicing endonuclease subunit 54
Description: Predicted to contribute to tRNA-intron endonuclease activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to localize to the tRNA-intron endonuclease complex. Implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ37147; hsSen54; PCH2A; PCH4; PCH5; sen54; SEN54 homolog; SEN54L; tRNA-intron endonuclease Sen54; tRNA-splicing endonuclease subunit Sen54; TSEN54 tRNA splicing endonuclease subunit
Mus musculus (house mouse) : Tsen54 (tRNA splicing endonuclease subunit 54)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tsen54 (tRNA splicing endonuclease subunit 54)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tsen54 (tRNA splicing endonuclease subunit 54)
Pan paniscus (bonobo/pygmy chimpanzee) : TSEN54 (tRNA splicing endonuclease subunit 54)
Canis lupus familiaris (dog) : TSEN54 (tRNA splicing endonuclease subunit 54)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tsen54 (tRNA splicing endonuclease subunit 54)
Sus scrofa (pig) : TSEN54 (tRNA splicing endonuclease subunit 54)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381775,516,528 - 75,524,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371773,512,609 - 73,520,821 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,024,204 - 71,032,415 (+)NCBINCBI36hg18NCBI36
Cytogenetic Map17q25.1NCBI
HuRef1768,936,266 - 68,944,477 (+)NCBIHuRef
CHM1_11773,577,646 - 73,585,857 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TSEN54
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1602635
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.