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Gene: OTULIN (OTU deubiquitinase with linear linkage specificity) Homo sapiens
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Symbol: OTULIN
Name: OTU deubiquitinase with linear linkage specificity
Description: Exhibits thiol-dependent ubiquitin-specific protease activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of defense response. Localizes to the cytoplasm. Predicted to colocalize with the LUBAC complex. Implicated in otulipenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AIPDS; deubiquitinating enzyme otulin; FAM105B; family with sequence similarity 105, member B; FLJ34884; GUM; gumby; hypothetical protein LOC90268; OTU domain-containing deubiquitinase with linear linkage specificity; ubiquitin thioesterase Gumby; ubiquitin thioesterase otulin
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl514,664,664 - 14,699,850 (+)Ensembl
GRCh38514,660,794 - 14,716,552 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37514,664,783 - 14,699,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36514,717,783 - 14,752,842 (+)NCBINCBI36hg18NCBI36
Celera514,688,765 - 14,723,825 (+)NCBI
Cytogenetic Map5p15.2NCBI
HuRef514,637,385 - 14,672,668 (+)NCBIHuRef
CHM1_1514,664,551 - 14,699,610 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on OTULIN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1602667
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.