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Gene: KDM8 (lysine demethylase 8) Homo sapiens
Symbol: KDM8
Name: lysine demethylase 8
CRRD ID: 1602684
Description: Exhibits several functions, including histone demethylase activity (H3-K36 specific); methylated histone binding activity; and peptidase activity. Involved in several processes, including histone H3-K36 demethylation; protein destabilization; and regulation of transcription, DNA-templated. Localizes to cytosol and nucleoplasm. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: arginyl C3-hydroxylase KDM8; bifunctional peptidase and arginyl-hydroxylase JMJD5; FLJ13798; JmjC arginyl-hydroxylase; jmjC domain-containing protein 5; JMJD5; jumonji C domain-containing protein 5; jumonji domain containing 5; jumonji domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8; lysine (K)-specific demethylase 8; lysine-specific demethylase 8
Mus musculus (house mouse) : Kdm8 (lysine (K)-specific demethylase 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm8 (lysine demethylase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm8 (lysine demethylase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM8 (lysine demethylase 8)
Canis lupus familiaris (dog) : KDM8 (lysine demethylase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm8 (lysine demethylase 8)
Sus scrofa (pig) : KDM8 (lysine demethylase 8)
Chlorocebus sabaeus (African green monkey) : KDM8 (lysine demethylase 8)
Heterocephalus glaber (naked mole-rat) : Kdm8 (lysine demethylase 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1627,203,495 - 27,221,768 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1627,203,508 - 27,221,768 (+)EnsemblGRCh38hg38GRCh38
GRCh381627,203,486 - 27,222,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371627,214,807 - 27,233,089 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361627,122,317 - 27,140,544 (+)NCBINCBI36hg18NCBI36
Celera1625,993,442 - 26,011,724 (+)NCBI
Cytogenetic Map16p12.1NCBI
HuRef1625,303,702 - 25,321,984 (+)NCBIHuRef
CHM1_11628,226,511 - 28,244,793 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KDM8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1602684
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.