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Gene: CTPS2 (CTP synthase 2) Homo sapiens
Symbol: CTPS2
Name: CTP synthase 2
Description: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CTP synthase II; CTP synthetase 2; CTP synthetase isoform; CTP synthetase type 2; cytidine 5'-triphosphate synthetase 2; DKFZp686C17207; FLJ43358; MGC32997; UTP--ammonia ligase 2; UTP-ammonia ligase; UTP-ammonia ligase 2
Mus musculus (house mouse) : Ctps2 (cytidine 5'-triphosphate synthase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ctps2 (CTP synthase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctps2 (CTP synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CTPS2 (CTP synthase 2)
Canis lupus familiaris (dog) : CTPS2 (CTP synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctps2 (CTP synthase 2)
Sus scrofa (pig) : CTPS2 (CTP synthase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X16,587,999 - 16,712,979 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X16,606,122 - 16,731,059 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X16,516,043 - 16,640,980 (-)NCBINCBI36hg18NCBI36
CeleraX20,724,510 - 20,849,457 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX14,360,950 - 14,485,310 (-)NCBIHuRef
CHM1_1X16,636,520 - 16,761,530 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CTPS2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1602693
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.