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Gene: RUFY4 (RUN and FYVE domain containing 4) Homo sapiens
Symbol: RUFY4
Name: RUN and FYVE domain containing 4
Description: Exhibits phosphatidylinositol-3-phosphate binding activity. Involved in autophagosome assembly; cellular response to interleukin-4; and positive regulation of macroautophagy. Localizes to the autophagosome; INTERACTS WITH aflatoxin B1; valproic acid; 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ46536; RUN and FYVE domain-containing protein 4; ZFYVE31
Mus musculus (house mouse) : Rufy4 (RUN and FYVE domain containing 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rufy4 (RUN and FYVE domain containing 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rufy4 (RUN and FYVE domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RUFY4 (RUN and FYVE domain containing 4)
Canis lupus familiaris (dog) : RUFY4 (RUN and FYVE domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rufy4 (RUN and FYVE domain containing 4)
Sus scrofa (pig) : RUFY4 (RUN and FYVE domain containing 4)
Chlorocebus sabaeus (African green monkey) : RUFY4 (RUN and FYVE domain containing 4)
Heterocephalus glaber (naked mole-rat) : Rufy4 (RUN and FYVE domain containing 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2218,034,960 - 218,090,581 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,034,934 - 218,090,584 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372218,899,657 - 218,955,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,646,285 - 218,663,108 (+)NCBINCBI36hg18NCBI36
Celera2212,667,545 - 212,721,497 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2210,753,571 - 210,795,629 (+)NCBIHuRef
HuRef2210,806,734 - 210,808,063 (+)NCBIHuRef
CHM1_12218,906,131 - 218,961,799 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on RUFY4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1602820
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.