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Gene: P3H1 (prolyl 3-hydroxylase 1) Homo sapiens
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Symbol: P3H1
Name: prolyl 3-hydroxylase 1
CRRD ID: 1602868
Description: Predicted to contribute to collagen binding activity. Involved in several processes, including negative regulation of post-translational protein modification; protein hydroxylation; and protein stabilization. Localizes to endoplasmic reticulum and nucleus. Colocalizes with collagen-containing extracellular matrix. Implicated in osteogenesis imperfecta type 8.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GROS1; growth suppressor 1; LEPRE1; leprecan; leucine proline-enriched proteoglycan (leprecan) 1; leucine- and proline-enriched proteoglycan 1; MGC117314; OI8; procollagen-proline 3-dioxygenase
Orthologs:
Mus musculus (house mouse) : P3h1 (prolyl 3-hydroxylase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : P3h1 (prolyl 3-hydroxylase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P3h1 (prolyl 3-hydroxylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : P3H1 (prolyl 3-hydroxylase 1)
Canis lupus familiaris (dog) : P3H1 (prolyl 3-hydroxylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P3h1 (prolyl 3-hydroxylase 1)
Sus scrofa (pig) : P3H1 (prolyl 3-hydroxylase 1)
Chlorocebus sabaeus (African green monkey) : P3H1 (prolyl 3-hydroxylase 1)
Heterocephalus glaber (naked mole-rat) : P3h1 (prolyl 3-hydroxylase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl142,746,335 - 42,767,084 (-)EnsemblGRCh38hg38GRCh38
GRCh38142,746,374 - 42,767,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37143,212,006 - 43,232,755 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36142,984,633 - 43,005,270 (-)NCBINCBI36hg18NCBI36
Celera141,493,937 - 41,514,687 (-)NCBI
Cytogenetic Map1p34.2NCBI
HuRef141,331,989 - 41,352,738 (-)NCBIHuRef
CHM1_1143,328,805 - 43,349,560 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on P3H1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1602868
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.