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Gene: NLGN4X (neuroligin 4 X-linked) Homo sapiens
Symbol: NLGN4X
Name: neuroligin 4 X-linked
Description: This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ASPGX2; AUTSX2; HLNX; HNL4X; HNLX; KIAA1260; MGC22376; neuroligin 4; neuroligin 4, X-linked; neuroligin X; neuroligin-4, X-linked; NLGN; NLGN4
Chinchilla lanigera (long-tailed chinchilla) : Nlgn4x (neuroligin 4 X-linked)
Pan paniscus (bonobo/pygmy chimpanzee) : NLGN4X (neuroligin 4, X-linked)
Canis lupus familiaris (dog) : NLGN4X (neuroligin 4 X-linked)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlgn4x (neuroligin 4 X-linked)
Sus scrofa (pig) : LOC100624109 (neuroligin-4, X-linked)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X5,890,026 - 6,228,882 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X5,808,067 - 6,146,916 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X5,818,083 - 6,156,706 (-)NCBINCBI36hg18NCBI36
CeleraX10,032,940 - 10,372,016 (-)NCBI
Cytogenetic MapXp22.32-p22.31NCBI
HuRefX3,686,314 - 4,028,458 (-)NCBIHuRef
CHM1_1X5,839,610 - 6,178,287 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NLGN4X
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603020
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.