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Gene: DESI2 (desumoylating isopeptidase 2) Homo sapiens
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Symbol: DESI2
Name: desumoylating isopeptidase 2
Description: Exhibits Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in protein deubiquitination. Predicted to localize to cytoplasm; INTERACTS WITH all-trans-retinoic acid; antirheumatic drug; arsenous acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C1orf121; CGI-146; chromosome 1 open reading frame 121; DESI; DeSI-2; DESI1; desumoylating isopeptidase 1; deubiquitinase DESI2; FAM152A; family with sequence similarity 152, member A; FLJ21998; PNAS-4; PPPDE peptidase domain containing 1; PPPDE peptidase domain-containing protein 1; PPPDE1
Orthologs:
Mus musculus (house mouse) : Desi2 (desumoylating isopeptidase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Desi2 (desumoylating isopeptidase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Desi2 (desumoylating isopeptidase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DESI2 (desumoylating isopeptidase 2)
Canis lupus familiaris (dog) : DESI2 (desumoylating isopeptidase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Desi2 (desumoylating isopeptidase 2)
Sus scrofa (pig) : DESI2 (desumoylating isopeptidase 2)
Chlorocebus sabaeus (African green monkey) : DESI2 (desumoylating isopeptidase 2)
Heterocephalus glaber (naked mole-rat) : Desi2 (desumoylating isopeptidase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1244,653,103 - 244,709,033 (+)EnsemblGRCh38hg38GRCh38
GRCh381244,652,760 - 244,709,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371244,816,352 - 244,872,335 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361242,882,975 - 242,938,958 (+)NCBINCBI36hg18NCBI36
Celera1218,106,243 - 218,162,211 (+)NCBI
Cytogenetic Map1q44NCBI
HuRef1215,199,549 - 215,255,506 (+)NCBIHuRef
CHM1_11246,088,654 - 246,144,629 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DESI2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603047
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.