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Gene: RNF128 (ring finger protein 128) Homo sapiens
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Symbol: RNF128
Name: ring finger protein 128
Description: The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase RNF128; FLJ23516; gene related to anergy in lymphocytes protein; GRAIL; ring finger protein 128, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF128
Orthologs:
Mus musculus (house mouse) : Rnf128 (ring finger protein 128)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf128 (ring finger protein 128)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf128 (ring finger protein 128)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF128 (ring finger protein 128)
Canis lupus familiaris (dog) : RNF128 (ring finger protein 128)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf128 (ring finger protein 128)
Sus scrofa (pig) : RNF128 (ring finger protein 128)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X106,693,838 - 106,797,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X105,937,068 - 106,040,246 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X105,823,724 - 105,926,902 (+)NCBINCBI36hg18NCBI36
CeleraX106,408,414 - 106,511,630 (+)NCBI
Cytogenetic MapXq22.3NCBI
HuRefX95,565,095 - 95,667,917 (+)NCBIHuRef
CHM1_1X105,847,889 - 105,951,066 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RNF128
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603197
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.