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Gene: RNF128 (ring finger protein 128) Homo sapiens
Symbol: RNF128
Name: ring finger protein 128
Description: The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase RNF128; FLJ23516; gene related to anergy in lymphocytes protein; GRAIL; ring finger protein 128, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF128
Mus musculus (house mouse) : Rnf128 (ring finger protein 128)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf128 (ring finger protein 128)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf128 (ring finger protein 128)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF128 (ring finger protein 128)
Canis lupus familiaris (dog) : RNF128 (ring finger protein 128)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf128 (ring finger protein 128)
Sus scrofa (pig) : RNF128 (ring finger protein 128)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X106,693,838 - 106,797,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X105,937,068 - 106,040,246 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X105,823,724 - 105,926,902 (+)NCBINCBI36hg18NCBI36
CeleraX106,408,414 - 106,511,630 (+)NCBI
Cytogenetic MapXq22.3NCBI
HuRefX95,565,095 - 95,667,917 (+)NCBIHuRef
CHM1_1X105,847,889 - 105,951,066 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RNF128
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603197
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.