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Gene: CR1 (complement C3b/C4b receptor 1 (Knops blood group)) Homo sapiens
Symbol: CR1
Name: complement C3b/C4b receptor 1 (Knops blood group)
CRRD ID: 1603411
Description: Exhibits complement receptor activity and opsonin binding activity. Involved in negative regulation of complement activation and regulation of serine-type endopeptidase activity. Localizes to cell surface and integral component of plasma membrane. Implicated in malaria.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C3-binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); complement component 3b/4b receptor 1 (Knops blood group); complement component receptor 1; complement receptor 1; complement receptor type 1; KN; Knops blood group antigen
Pan paniscus (bonobo/pygmy chimpanzee) : CR1 (complement C3b/C4b receptor 1 (Knops blood group))
Canis lupus familiaris (dog) : CR1L (complement C3b/C4b receptor 1 like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cr1 (complement C3b/C4b receptor 1 (Knops blood group))
Sus scrofa (pig) : CR1 (complement C3b/C4b receptor 1 (Knops blood group))
Chlorocebus sabaeus (African green monkey) : CR1 (complement C3b/C4b receptor 1 (Knops blood group))
more info ...
Related Pseudogenes: LOC100422434  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1207,496,147 - 207,641,765 (+)EnsemblGRCh38hg38GRCh38
GRCh381207,496,157 - 207,641,765 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371207,669,473 - 207,815,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,736,096 - 205,881,733 (+)NCBINCBI36hg18NCBI36
Celera1180,918,501 - 181,045,588 (+)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1178,362,547 - 178,489,425 (+)NCBIHuRef
CHM1_11208,942,210 - 209,087,469 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CR1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603411
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.