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Gene: VCX3B (variable charge X-linked 3B) Homo sapiens
Symbol: VCX3B
Name: variable charge X-linked 3B
Description: This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22, and the Y-linked members are two identical copies of the gene within a palindromic region on chromosome Yq11. The family members share a high degree of sequence identity, with the exception that a 30-nt unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This family member, as represented by the reference genome allele, contains 14 copies of the 30-nt repeat unit. VCX/Y genes encode small and highly charged proteins containing putative bipartite nuclear localization signals. Although the exact function of this family member has yet to be determined, a role in mRNA stability regulation can be inferred from the ability of the highly similar family member, VCX-A, to inhibit mRNA decapping. A possible role in the regulation of ribosome assembly during spermatogenesis has also been suggested. [provided by RefSeq, Aug 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC119815; variable charge X-linked protein 3B; variable charge, X-linked 3B; variably charged protein X-C; VCX-C; VCXC
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X8,464,830 - 8,466,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X8,432,871 - 8,434,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X8,392,871 - 8,394,551 (+)NCBINCBI36hg18NCBI36
CeleraX12,610,915 - 12,612,595 (+)NCBI
Cytogenetic MapXp22.31NCBI
CHM1_1X8,463,873 - 8,465,553 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on VCX3B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603458
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.