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Gene: TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3) Homo sapiens
Symbol: TAB3
Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Description: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MAP3K7IP3; MGC45404; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; NAP1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
Related Pseudogenes: TAB3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X30,827,442 - 30,889,391 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X30,845,559 - 30,907,511 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X30,755,480 - 30,817,432 (-)NCBINCBI36hg18NCBI36
CeleraX34,973,775 - 35,018,119 (-)NCBI
Cytogenetic MapXp21.2NCBI
HuRefX28,586,659 - 28,648,837 (-)NCBIHuRef
CHM1_1X30,877,115 - 30,938,957 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TAB3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603527
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.