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Gene: SH2B1 (SH2B adaptor protein 1) Homo sapiens
Symbol: SH2B1
Name: SH2B adaptor protein 1
Description: Predicted to have transmembrane receptor protein tyrosine kinase adaptor activity. Involved in positive regulation of SMAD protein signal transduction. Predicted to localize to the plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp547G1110; FLJ30542; KIAA1299; pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B; SH2 domain-containing putative adapter SH2-B; SH2-B signaling protein; SH2B; SH2B adapter protein 1
Mus musculus (house mouse) : Sh2b1 (SH2B adaptor protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sh2b1 (SH2B adaptor protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b1 (SH2B adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B1 (SH2B adaptor protein 1)
Canis lupus familiaris (dog) : SH2B1 (SH2B adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b1 (SH2B adaptor protein 1)
Sus scrofa (pig) : SH2B1 (SH2B adaptor protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381628,846,600 - 28,874,213 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371628,872,939 - 28,885,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,782,815 - 28,793,027 (+)NCBINCBI36hg18NCBI36
Celera1627,829,836 - 27,840,291 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1626,742,418 - 26,752,871 (+)NCBIHuRef
CHM1_11629,869,765 - 29,897,372 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SH2B1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603671
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.