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Gene: SH2B1 (SH2B adaptor protein 1) Homo sapiens
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Symbol: SH2B1
Name: SH2B adaptor protein 1
Description: Predicted to have transmembrane receptor protein tyrosine kinase adaptor activity. Involved in positive regulation of SMAD protein signal transduction. Predicted to localize to the plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp547G1110; FLJ30542; KIAA1299; pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B; SH2 domain-containing putative adapter SH2-B; SH2-B signaling protein; SH2B; SH2B adapter protein 1
Orthologs:
Mus musculus (house mouse) : Sh2b1 (SH2B adaptor protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sh2b1 (SH2B adaptor protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b1 (SH2B adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B1 (SH2B adaptor protein 1)
Canis lupus familiaris (dog) : SH2B1 (SH2B adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b1 (SH2B adaptor protein 1)
Sus scrofa (pig) : SH2B1 (SH2B adaptor protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,846,600 - 28,874,213 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371628,872,939 - 28,885,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,782,815 - 28,793,027 (+)NCBINCBI36hg18NCBI36
Celera1627,829,836 - 27,840,291 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1626,742,418 - 26,752,871 (+)NCBIHuRef
CHM1_11629,869,765 - 29,897,372 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SH2B1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603671
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.