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Gene: SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2) Homo sapiens
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Symbol: SRGAP2
Name: SLIT-ROBO Rho GTPase activating protein 2
Description: Exhibits GTPase activator activity; Rac GTPase binding activity; and protein homodimerization activity. Involved in several processes, including generation of neurons; plasma membrane bounded cell projection assembly; and substrate adhesion-dependent cell spreading. Localizes to several cellular components, including the dendritic spine head; lamellipodium; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARHGAP34; FNBP2; formin binding protein 2; formin-binding protein 2; KIAA0456; rho GTPase-activating protein 34; RP11-312O7.2; SLIT-ROBO GAP2; SLIT-ROBO Rho GTPase-activating protein 2; SRGAP2A; srGAP3
Orthologs:
Mus musculus (house mouse) : Srgap2 (SLIT-ROBO Rho GTPase activating protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Srgap2 (SLIT-ROBO Rho GTPase activating protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srgap2 (SLIT-ROBO Rho GTPase activating protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2)
Canis lupus familiaris (dog) : SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srgap2 (SLIT-ROBO Rho GTPase activating protein 2)
Sus scrofa (pig) : SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,203,556 - 206,464,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371206,135,293 - 206,135,657 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371206,516,197 - 206,637,783 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,582,823 - 204,704,406 (+)NCBINCBI36hg18NCBI36
Celera1179,840,685 - 179,889,229 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1177,269,281 - 177,336,031 (+)NCBIHuRef
CHM1_11207,650,968 - 207,909,982 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SRGAP2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603684
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.