Gene: ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1) Homo sapiens
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Symbol: ST8SIA1
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Description: Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-2,8-sialyltransferase 8A; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; disialoganglioside (GD3) synthase; ganglioside GD3 synthase; ganglioside GT3 synthase; ganglioside-specific alpha-2,8-polysialyltransferase; GD3S; sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase) A; sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase); sialyltransferase St8Sia I; sialytransferase St8Sia I; SIAT8; SIAT8-A; SIAT8A; ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1; ST8SiaI
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381222,193,391 - 22,334,714 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371222,346,325 - 22,487,648 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361222,245,200 - 22,378,915 (-)NCBINCBI36hg18NCBI36
Celera1227,500,769 - 27,642,080 (-)NCBI
Cytogenetic Map12p12.1NCBI
HuRef1222,119,372 - 22,260,647 (-)NCBIHuRef
CHM1_11222,311,335 - 22,452,993 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ST8SIA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603707
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-02-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.