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Gene: KNG1 (kininogen 1) Homo sapiens
Symbol: KNG1
Name: kininogen 1
Description: Exhibits cysteine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and positive regulation of cytosolic calcium ion concentration. Localizes to the extracellular space. Biomarker of Henoch-Schoenlein purpura and proliferative vitreoretinopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-2-thiol proteinase inhibitor; BDK; BK; bradykinin; fitzgerald factor; high molecular weight kininogen; HMWK; kininogen-1; KNG; williams-Fitzgerald-Flaujeac factor
Mus musculus (house mouse) : Kng2 (kininogen 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kng2 (kininogen 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kng1 (kininogen 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KNG1 (kininogen 1)
Canis lupus familiaris (dog) : KNG1 (kininogen 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kng1 (kininogen 1)
Sus scrofa (pig) : KNG1 (kininogen 1)
Chlorocebus sabaeus (green monkey) : KNG1 (kininogen 1)
Heterocephalus glaber (naked mole-rat) : Kng1 (kininogen 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3186,717,348 - 186,744,410 (+)Ensembl
GRCh383186,717,359 - 186,744,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373186,435,098 - 186,462,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363187,917,814 - 187,944,437 (+)NCBINCBI36hg18NCBI36
Celera3184,871,536 - 184,898,662 (+)NCBI
Cytogenetic Map3q27.3NCBI
HuRef3183,844,775 - 183,871,713 (+)NCBIHuRef
CHM1_13186,399,036 - 186,425,781 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KNG1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603713
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.