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Gene: CCR2 (C-C motif chemokine receptor 2) Homo sapiens
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Symbol: CCR2
Name: C-C motif chemokine receptor 2
CRRD ID: 1603716
Description: Exhibits CCR2 chemokine receptor binding activity. Involved in cytokine-mediated signaling pathway; positive regulation of astrocyte chemotaxis; and positive regulation of monocyte chemotaxis. Localizes to cytoplasm and plasma membrane. Implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); diabetes mellitus (multiple); and uveitis (multiple). Biomarker of several diseases, including lung disease (multiple); macular degeneration (multiple); myeloid sarcoma; myositis (multiple); and periapical granuloma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; FLJ78302; MCP-1 receptor; MCP-1-R; MGC103828; MGC111760; MGC168006; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Orthologs:
Mus musculus (house mouse) : Ccr2 (chemokine (C-C motif) receptor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccr2 (C-C motif chemokine receptor 2)
Chinchilla lanigera (long-tailed chinchilla) : Ccr2 (C-C motif chemokine receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CCR2 (C-C motif chemokine receptor 2)
Canis lupus familiaris (dog) : CCR2 (C-C motif chemokine receptor 2)
Sus scrofa (pig) : CCR2 (C-C motif chemokine receptor 2)
Chlorocebus sabaeus (African green monkey) : CCR2 (C-C motif chemokine receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,353,734 - 46,360,928 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl346,353,744 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,395,235 - 46,402,413 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CCR2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603716
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.