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Gene: DDI2 (DNA damage inducible 1 homolog 2) Homo sapiens
Symbol: DDI2
Name: DNA damage inducible 1 homolog 2
Description: Exhibits aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Localizes to the cytosol and nucleoplasm; INTERACTS WITH 17beta-estradiol; aflatoxin B2; arsenous acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DDI1, DNA-damage inducible 1, homolog 2; DNA-damage inducible 1 homolog 2; DNA-damage inducible protein 2 (DDI2); MGC14844; protein DDI1 homolog 2; RP4-680D5.5
Mus musculus (house mouse) : Ddi2 (DNA-damage inducible protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddi2 (DNA damage inducible 1 homolog 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddi2 (DNA damage inducible 1 homolog 2)
Canis lupus familiaris (dog) : DDI2 (DNA damage inducible 1 homolog 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101968969 (protein DDI1 homolog 2)
Chlorocebus sabaeus (green monkey) : DDI2 (DNA damage inducible 1 homolog 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl115,617,458 - 15,669,044 (+)Ensembl
GRCh38115,617,458 - 15,669,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37115,943,953 - 15,995,539 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,816,657 - 15,859,335 (+)NCBINCBI36hg18NCBI36
Celera114,426,817 - 14,470,431 (+)NCBI
Cytogenetic Map1p36.21NCBI
HuRef114,463,422 - 14,506,965 (+)NCBIHuRef
CHM1_1115,742,627 - 15,786,290 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DDI2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603951
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.