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Gene: DOCK8 (dedicator of cytokinesis 8) Homo sapiens
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Symbol: DOCK8
Name: dedicator of cytokinesis 8
Description: Exhibits guanyl-nucleotide exchange factor activity. Involved in several processes, including memory T cell proliferation; positive regulation of T cell migration; and positive regulation of establishment of T cell polarity. Localizes to the cytoplasm and leading edge membrane. Implicated in autosomal dominant non-syndromic intellectual disability 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1200017A24Rik; dedicator of cytokinesis protein 8; epididymis luminal protein 205; FLJ00026; FLJ00152; FLJ00346; HEL-205; MRD2; ZIR8
Orthologs:
Mus musculus (house mouse) : Dock8 (dedicator of cytokinesis 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dock8 (dedicator of cytokinesis 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock8 (dedicator of cytokinesis 8)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK8 (dedicator of cytokinesis 8)
Canis lupus familiaris (dog) : DOCK8 (dedicator of cytokinesis 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock8 (dedicator of cytokinesis 8)
Sus scrofa (pig) : DOCK8 (dedicator of cytokinesis 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389211,296 - 465,260 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379214,865 - 465,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369263,048 - 455,255 (+)NCBINCBI36hg18NCBI36
Celera9129,697 - 382,253 (+)NCBI
Cytogenetic Map9p24.3NCBI
HuRef9168,609 - 417,080 (+)NCBIHuRef
CHM1_19215,319 - 464,907 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DOCK8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603953
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.