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Gene: PORCN (porcupine O-acyltransferase) Homo sapiens
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Symbol: PORCN
Name: porcupine O-acyltransferase
Description: This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2410004O13Rik; dermal hypoplasia, focal; DHOF; FODH; MG61; MGC29687; por; PORC; porcupine homolog; porcupine homolog (Drosophila); PPN; probable protein-cysteine N-palmitoyltransferase porcupine; protein-cysteine N-palmitoyltransferase porcupine; protein-serine O-palmitoleoyltransferase porcupine
Orthologs:
Mus musculus (house mouse) : Porcn (porcupine O-acyltransferase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Porcn (porcupine O-acyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Porcn (porcupine O-acyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : PORCN (porcupine O-acyltransferase)
Canis lupus familiaris (dog) : PORCN (porcupine O-acyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Porcn (porcupine O-acyltransferase)
Sus scrofa (pig) : PORCN (porcupine O-acyltransferase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,508,959 - 48,520,814 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X48,367,347 - 48,379,202 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,252,315 - 48,264,146 (+)NCBINCBI36hg18NCBI36
CeleraX53,286,529 - 53,298,360 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,031,046 - 46,042,328 (+)NCBIHuRef
CHM1_1X48,398,612 - 48,410,463 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PORCN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1603972
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.