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Gene: CCL5 (C-C motif chemokine ligand 5) Homo sapiens
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Symbol: CCL5
Name: C-C motif chemokine ligand 5
Description: Exhibits several functions, including CCR chemokine receptor binding activity; molecular function regulator; and phosphatidylinositol phospholipase C activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell migration; and positive regulation of cell-cell adhesion. Predicted to localize to the extracellular space. Implicated in asthma; hepatitis C; pancreatitis; pulmonary tuberculosis; and type 1 diabetes mellitus. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension (multiple); invasive ductal carcinoma; lung disease (multiple); and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta-chemokine RANTES; C-C motif chemokine 5; chemokine (C-C motif) ligand 5; D17S136E; eoCP; eosinophil chemotactic cytokine; MGC17164; RANTES; regulated upon activation, normally T-expressed, and presumably secreted; SCYA5; SIS-delta; SISd; small inducible cytokine A5 (RANTES); small inducible cytokine subfamily A (Cys-Cys), member 5; small-inducible cytokine A5; t cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES; TCP228
Orthologs:
Mus musculus (house mouse) : Ccl5 (chemokine (C-C motif) ligand 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccl5 (C-C motif chemokine ligand 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ccl5 (C-C motif chemokine ligand 5)
Pan paniscus (bonobo/pygmy chimpanzee) : CCL5 (C-C motif chemokine ligand 5)
Canis lupus familiaris (dog) : CCL5 (C-C motif chemokine ligand 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ccl5 (C-C motif chemokine ligand 5)
Sus scrofa (pig) : CCL5 (C-C motif chemokine ligand 5)
Chlorocebus sabaeus (green monkey) : CCL5 (C-C motif chemokine ligand 5)
Heterocephalus glaber (naked mole-rat) : Ccl5 (C-C motif chemokine ligand 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1735,871,491 - 35,880,793 (-)Ensembl
GRCh381735,871,491 - 35,880,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371734,198,495 - 34,207,377 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,222,608 - 31,231,490 (-)NCBINCBI36hg18NCBI36
Celera1731,108,052 - 31,116,934 (-)NCBI
Cytogenetic Map17q12NCBI
HuRef1730,383,508 - 30,392,390 (-)NCBIHuRef
CHM1_11734,263,060 - 34,271,942 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CCL5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604061
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.