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Gene: NLRC3 (NLR family CARD domain containing 3) Homo sapiens
Symbol: NLRC3
Name: NLR family CARD domain containing 3
Description: Predicted to have phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including negative regulation of NLRP3 inflammasome complex assembly; negative regulation of cytokine production; and negative regulation of intracellular signal transduction. Localizes to several cellular components, including the centriolar satellite; cytosol; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CARD15-like protein; caterpiller 16.2; caterpiller protein 16.2; CLR16.2; FLJ00348; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NOD-like receptor C3; NOD3; nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3
Mus musculus (house mouse) : Nlrc3 (NLR family, CARD domain containing 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nlrc3 (NLR family, CARD domain containing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrc3 (NLR family CARD domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRC3 (NLR family CARD domain containing 3)
Canis lupus familiaris (dog) : NLRC3 (NLR family CARD domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrc3 (NLR family CARD domain containing 3)
Sus scrofa (pig) : NLRC3 (NLR family CARD domain containing 3)
Chlorocebus sabaeus (African green monkey) : NLRC3 (NLR family CARD domain containing 3)
Heterocephalus glaber (naked mole-rat) : Nlrc3 (NLR family CARD domain containing 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl163,539,033 - 3,577,403 (-)Ensembl
GRCh38163,539,033 - 3,577,782 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37163,589,033 - 3,627,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,529,034 - 3,567,393 (-)NCBINCBI36hg18NCBI36
Celera163,795,793 - 3,834,163 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef163,558,668 - 3,596,656 (-)NCBIHuRef
CHM1_1163,589,077 - 3,627,406 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NLRC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604212
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.