Gene: VKORC1 (vitamin K epoxide reductase complex subunit 1) Homo sapiens
Analyze
Symbol:
VKORC1
Name:
vitamin K epoxide reductase complex subunit 1
Description:
Exhibits vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in several processes, including blood coagulation; peptidyl-glutamic acid carboxylation; and vitamin K metabolic process. Localizes to the endoplasmic reticulum. Implicated in inherited blood coagulation disease.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
EDTP308; FLJ00289; IMAGE3455200; MGC2694; MST134; MST576; phylloquinone epoxide reductase; vitamin K dependent clotting factors deficiency 2; vitamin K epoxide reductase complex, subunit 1; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); VKCFD2; VKOR
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Vkorc1 (vitamin K epoxide reductase complex, subunit 1) HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Vkorc1 (vitamin K epoxide reductase complex, subunit 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):
Vkorc1 (vitamin K epoxide reductase complex subunit 1) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
VKORC1 (vitamin K epoxide reductase complex subunit 1) NCBI
Ortholog
Canis lupus familiaris (dog):
VKORC1 (vitamin K epoxide reductase complex subunit 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Vkorc1 (vitamin K epoxide reductase complex subunit 1) NCBI
Ortholog
Sus scrofa (pig):
VKORC1 (vitamin K epoxide reductase complex subunit 1) HGNC
Ensembl, NCBI, OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Vkorc1 (vitamin K epoxide reductase complex, subunit 1)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Vkorc1 (vitamin K epoxide reductase complex, subunit 1)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
vkorc1 (vitamin K epoxide reductase complex, subunit 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
Vkor
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
VKORC1P1
VKORC1P2
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 16 31,090,842 - 31,094,999 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 16 31,102,175 - 31,106,699 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 16 31,009,676 - 31,013,777 (-) NCBI NCBI36 hg18 NCBI36 Celera 16 29,191,224 - 29,195,328 (+) NCBI Cytogenetic Map 16 p11.2 NCBI HuRef 16 28,663,874 - 28,667,978 (-) NCBI HuRef CHM1_1 16 32,419,464 - 32,423,640 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
branched-chain keto acid dehydrogenase kinase deficiency IAGP RGD:13838492 8554872 ClinVar Annotator: match by term: Branched-chain keto acid dehydrogenase kinase deficiency ClinVar PMID:25741868 Coumarin Resistance IAGP RGD:8556698 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar PMID:15888487 more ... Coumarin Resistance IAGP RGD:8572612 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar PMID:15358623 more ... Coumarin Resistance IAGP RGD:15015166 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar PMID:25741868 Coumarin Resistance IAGP RGD:8654979 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar Coumarin Resistance IAGP RGD:8556695 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar PMID:14765194 Coumarin Resistance IAGP RGD:8556694 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar PMID:14765194 Coumarin Resistance IAGP RGD:8556697 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar PMID:14765194 Coumarin Resistance IAGP RGD:8556696 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar PMID:14765194 Coumarin Resistance IAGP RGD:9688553 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar Coumarin Resistance IAGP RGD:8556699 8554872 ClinVar Annotator: match by term: Coumarin resistance ClinVar PMID:17110455 more ... Coumarin Sensitivity IAGP RGD:8556698 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar PMID:15888487 more ... Coumarin Sensitivity IAGP RGD:8572612 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar PMID:15358623 more ... Coumarin Sensitivity IAGP RGD:15015166 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar PMID:25741868 Coumarin Sensitivity IAGP RGD:8654979 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar Coumarin Sensitivity IAGP RGD:8556695 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar PMID:14765194 Coumarin Sensitivity IAGP RGD:8556694 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar PMID:14765194 Coumarin Sensitivity IAGP RGD:8556697 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar PMID:14765194 Coumarin Sensitivity IAGP RGD:8556696 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar PMID:14765194 Coumarin Sensitivity IAGP RGD:9688553 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar Coumarin Sensitivity IAGP RGD:8556699 8554872 ClinVar Annotator: match by term: COUMARIN SENSITIVITY ClinVar PMID:17110455 more ... Vitamin K-Dependent Clotting Factors, Combined Deficiency of, 2 IAGP RGD:8556693 8554872 ClinVar Annotator: match by term: Vitamin k-dependent clotting factors, combined deficiency of, 2 ClinVar PMID:11154138 , PMID:14765194 Warfarin Sensitivity IAGP RGD:8572612 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar PMID:15358623 more ... Warfarin Sensitivity IAGP RGD:15015166 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar PMID:25741868 Warfarin Sensitivity IAGP RGD:8654979 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar Warfarin Sensitivity IAGP RGD:8556695 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar PMID:14765194 Warfarin Sensitivity IAGP RGD:8556694 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar PMID:14765194 Warfarin Sensitivity IAGP RGD:8556697 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar PMID:14765194 Warfarin Sensitivity IAGP RGD:8556696 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar PMID:14765194 Warfarin Sensitivity IAGP RGD:9688553 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar Warfarin Sensitivity IAGP RGD:8556699 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar PMID:17110455 more ... Warfarin Sensitivity IAGP RGD:8556698 8554872 ClinVar Annotator: match by term: Warfarin sensitivity ClinVar PMID:15888487 more ...
Imported Annotations - CTD
Aortic Rupture EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16549638 blood coagulation disease EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19141161 Coronary Disease EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16549638 Drug-Related Side Effects and Adverse Reactions EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26445138 Hemorrhage EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20597268 , PMID:26445138 Stroke EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16549638 thrombosis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29581108 vascular disease EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16549638 Vitamin K-Dependent Clotting Factors, Combined Deficiency of, 2 EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14765194 Imported Annotations - OMIM
Coumarin Resistance IAGP 7240710 OMIM Vitamin K-Dependent Clotting Factors, Combined Deficiency of, 2 IAGP 7240710 OMIM
(+)-schisandrin B multiple interactions ISO RGD:1303107 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of VKORC1 mRNA] CTD PMID:31150632 17alpha-ethynylestradiol multiple interactions ISO RGD:1332416 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VKORC1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:1303107 6480464 Ethinyl Estradiol results in decreased expression of VKORC1 mRNA CTD PMID:17557909 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1332416 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VKORC1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1303107 6480464 Tetrachlorodibenzodioxin results in decreased expression of VKORC1 mRNA CTD PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1303107 6480464 Tetrachlorodibenzodioxin affects the expression of VKORC1 mRNA CTD PMID:22298810 2,3,7,8-Tetrachlorodibenzofuran decreases expression ISO RGD:1303107 6480464 2 more ... CTD PMID:21724226 2,4-dinitrotoluene affects expression ISO RGD:1303107 6480464 2, 4-dinitrotoluene affects the expression of VKORC1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1303107 6480464 2, 6-dinitrotoluene affects the expression of VKORC1 mRNA CTD PMID:21346803 3-chloropropane-1,2-diol increases expression ISO RGD:1303107 6480464 alpha-Chlorohydrin results in increased expression of VKORC1 mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VKORC1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of VKORC1 mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1332416 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of VKORC1 mRNA CTD PMID:18648102 4-hydroxycoumarin multiple interactions EXP 6480464 4-hydroxycoumarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 4-hydroxycoumarin decreases activity EXP 6480464 4-hydroxycoumarin results in decreased activity of VKORC1 protein CTD PMID:29581108 acenocoumarol affects response to substance EXP 6480464 VKORC1 gene polymorphism affects the susceptibility to Acenocoumarol more ... CTD PMID:16201835 more ... acenocoumarol decreases activity EXP 6480464 Acenocoumarol results in decreased activity of VKORC1 protein CTD PMID:29581108 acenocoumarol multiple interactions EXP 6480464 Acenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 acenocoumarol increases response to substance EXP 6480464 VKORC1 protein results in increased susceptibility to Acenocoumarol CTD PMID:16869821 acenocoumarol decreases response to substance EXP 6480464 VKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumarol, VKORC1 protein polymorphism results in decreased susceptibility to Acenocoumarol CTD PMID:17036862 , PMID:19875892 acetylsalicylic acid increases response to substance EXP 6480464 VKORC1 gene SNP results in increased susceptibility to Aspirin CTD PMID:28338108 acrylamide decreases expression ISO RGD:1303107 6480464 Acrylamide results in decreased expression of VKORC1 mRNA CTD PMID:28959563 benzo[a]pyrene multiple interactions ISO RGD:1332416 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to VKORC1 promoter] CTD PMID:19654925 benzo[a]pyrene decreases expression ISO RGD:1332416 6480464 Benzo(a)pyrene results in decreased expression of VKORC1 mRNA CTD PMID:27195522 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of VKORC1 mRNA CTD PMID:20106945 bisphenol A increases expression ISO RGD:1303107 6480464 bisphenol A results in increased expression of VKORC1 mRNA CTD PMID:25181051 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of VKORC1 mRNA CTD PMID:30903817 bisphenol A multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VKORC1 mRNA CTD PMID:28628672 bisphenol F multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of VKORC1 mRNA CTD PMID:28628672 Brodifacoum multiple interactions EXP 6480464 bromfenacoum inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 Brodifacoum decreases activity EXP 6480464 bromfenacoum results in decreased activity of VKORC1 protein CTD PMID:29581108 Bromadiolone affects response to substance ISO RGD:1303107 6480464 VKORC1 protein affects the susceptibility to bromadiolone CTD PMID:17994578 Bromadiolone multiple interactions EXP 6480464 bromadiolone inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 Bromadiolone decreases activity EXP 6480464 bromadiolone results in decreased activity of VKORC1 protein CTD PMID:29581108 Bromadiolone decreases response to substance ISO RGD:1332416 6480464 VKORC1 protein polymorphism results in decreased susceptibility to bromadiolone CTD PMID:27117082 Bromadiolone decreases response to substance ISO RGD:1303107 6480464 VKORC1 gene mutant form results in decreased susceptibility to bromadiolone more ... CTD PMID:17994578 more ... C60 fullerene decreases expression ISO RGD:1303107 6480464 fullerene C60 results in decreased expression of VKORC1 mRNA CTD PMID:19167457 carbon nanotube decreases expression ISO RGD:1332416 6480464 Nanotubes, Carbon analog results in decreased expression of VKORC1 mRNA, Nanotubes, Carbon results in decreased expression of VKORC1 mRNA CTD PMID:25554681 , PMID:25620056 Chlorophacinone decreases response to substance ISO RGD:1303107 6480464 VKORC1 gene mutant form results in decreased susceptibility to chlorophacinone CTD PMID:19752778 chloropicrin increases expression EXP 6480464 chloropicrin results in increased expression of VKORC1 mRNA CTD PMID:26352163 choline multiple interactions ISO RGD:1332416 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VKORC1 gene CTD PMID:20938992 cisplatin increases expression ISO RGD:1332416 6480464 Cisplatin results in increased expression of VKORC1 mRNA CTD PMID:25270620 clobetasol increases expression ISO RGD:1332416 6480464 Clobetasol results in increased expression of VKORC1 mRNA CTD PMID:27462272 clofibrate decreases expression ISO RGD:1332416 6480464 Clofibrate results in decreased expression of VKORC1 mRNA CTD PMID:17585979 clofibric acid multiple interactions ISO RGD:1303107 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of VKORC1 mRNA CTD PMID:17602206 copper atom decreases expression ISO RGD:1303107 6480464 Copper results in decreased expression of VKORC1 mRNA CTD PMID:22465980 , PMID:30556269 copper(0) decreases expression ISO RGD:1303107 6480464 Copper results in decreased expression of VKORC1 mRNA CTD PMID:22465980 , PMID:30556269 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of VKORC1 mRNA CTD PMID:19549813 Coumachlor decreases activity EXP 6480464 coumachlor results in decreased activity of VKORC1 protein CTD PMID:29581108 Coumachlor multiple interactions EXP 6480464 coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1], coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide] CTD PMID:29581108 coumarin decreases response to substance EXP 6480464 VKORC1 gene mutant form results in decreased susceptibility to coumarin CTD PMID:18278162 coumarin increases response to substance EXP 6480464 VKORC1 gene mutant form results in increased susceptibility to coumarin, VKORC1 promoter SNP results in increased susceptibility to coumarin CTD PMID:17849045 , PMID:18278162 coumarins affects activity EXP 6480464 Coumarins affects the activity of VKORC1 protein CTD PMID:18278162 Coumatetralyl decreases response to substance ISO RGD:1332416 6480464 VKORC1 protein polymorphism results in decreased susceptibility to coumatetralyl CTD PMID:27117082 Coumatetralyl decreases activity EXP 6480464 coumatetralyl results in decreased activity of VKORC1 protein CTD PMID:29581108 Coumatetralyl multiple interactions EXP 6480464 coumatetralyl inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 Coumatetralyl decreases response to substance ISO RGD:1303107 6480464 VKORC1 protein polymorphism results in decreased susceptibility to coumatetralyl CTD PMID:27117082 coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of VKORC1 mRNA CTD PMID:20106945 dehydroacetic acid decreases activity ISO RGD:1303107 6480464 dehydroacetic acid results in decreased activity of VKORC1 protein CTD PMID:17941040 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VKORC1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of VKORC1 mRNA CTD PMID:28628672 dibutyl phthalate decreases expression ISO RGD:1303107 6480464 Dibutyl Phthalate results in decreased expression of VKORC1 mRNA CTD PMID:17379624 , PMID:21266533 dicoumarol decreases activity EXP 6480464 Dicumarol results in decreased activity of VKORC1 protein CTD PMID:29581108 dicoumarol multiple interactions EXP 6480464 Dicumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 Difenacoum decreases response to substance ISO RGD:1332416 6480464 VKORC1 protein polymorphism results in decreased susceptibility to difenacoum CTD PMID:27117082 Difenacoum decreases response to substance ISO RGD:1303107 6480464 VKORC1 protein mutant form results in decreased susceptibility to difenacoum, VKORC1 protein polymorphism results in decreased susceptibility to difenacoum CTD PMID:27117082 , PMID:29155484 dioxygen multiple interactions ISO RGD:1332416 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of VKORC1 mRNA CTD PMID:30529165 disodium selenite decreases expression EXP 6480464 Sodium Selenite results in decreased expression of VKORC1 mRNA CTD PMID:18175754 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VKORC1 mRNA CTD PMID:27188386 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of VKORC1 mRNA CTD PMID:29803840 elemental selenium multiple interactions EXP 6480464 [Selenium co-treated with Vitamin E] results in increased expression of VKORC1 mRNA CTD PMID:19244175 elemental selenium increases expression EXP 6480464 Selenium results in increased expression of VKORC1 mRNA CTD PMID:19244175 Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of VKORC1 mRNA CTD PMID:19167446 etoposide increases expression ISO RGD:1332416 6480464 Etoposide results in increased expression of VKORC1 mRNA CTD PMID:25270620 fipronil decreases expression ISO RGD:1303107 6480464 fipronil results in decreased expression of VKORC1 mRNA CTD PMID:23962444 fluindione multiple interactions EXP 6480464 fluindione inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1], fluindione inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide] CTD PMID:29581108 fluindione decreases activity EXP 6480464 fluindione results in decreased activity of VKORC1 protein CTD PMID:29581108 folic acid multiple interactions ISO RGD:1332416 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VKORC1 gene CTD PMID:20938992 GW 4064 multiple interactions ISO RGD:1332416 6480464 GW 4064 promotes the reaction [NR1H4 protein binds to VKORC1 gene] CTD PMID:20091679 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VKORC1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of VKORC1 mRNA CTD PMID:28628672 L-methionine multiple interactions ISO RGD:1332416 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of VKORC1 gene CTD PMID:20938992 N-nitrosodiethylamine multiple interactions ISO RGD:1303107 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of VKORC1 mRNA CTD PMID:17602206 nefazodone decreases expression ISO RGD:1303107 6480464 nefazodone results in decreased expression of VKORC1 mRNA CTD PMID:24136188 paracetamol affects expression ISO RGD:1332416 6480464 Acetaminophen affects the expression of VKORC1 mRNA CTD PMID:17562736 phenindione multiple interactions EXP 6480464 Phenindione inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 phenindione decreases activity EXP 6480464 Phenindione results in decreased activity of VKORC1 protein CTD PMID:29581108 phenprocoumon affects response to substance EXP 6480464 VKORC1 gene polymorphism affects the susceptibility to Phenprocoumon, VKORC1 intron SNP affects the susceptibility to Phenprocoumon CTD PMID:15536456 more ... phenprocoumon multiple interactions EXP 6480464 Phenprocoumon inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] CTD PMID:29581108 phenprocoumon decreases activity EXP 6480464 Phenprocoumon results in decreased activity of VKORC1 protein CTD PMID:29581108 phenprocoumon decreases response to substance EXP 6480464 VKORC1 protein polymorphism results in decreased susceptibility to Phenprocoumon CTD PMID:17036862 phylloquinone multiple interactions EXP 6480464 4-hydroxycoumarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1] more ... CTD PMID:29581108 phylloquinone increases reduction EXP 6480464 VKORC1 protein results in increased reduction of Vitamin K 1 CTD PMID:29581108 resveratrol multiple interactions EXP 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of VKORC1 mRNA CTD PMID:19167446 rotenone decreases expression ISO RGD:1303107 6480464 Rotenone results in decreased expression of VKORC1 mRNA CTD PMID:28374803 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VKORC1 mRNA CTD PMID:27188386 selenium atom multiple interactions EXP 6480464 [Selenium co-treated with Vitamin E] results in increased expression of VKORC1 mRNA CTD PMID:19244175 selenium atom increases expression EXP 6480464 Selenium results in increased expression of VKORC1 mRNA CTD PMID:19244175 tetrachloromethane decreases expression ISO RGD:1303107 6480464 Carbon Tetrachloride results in decreased expression of VKORC1 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:1303107 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of VKORC1 mRNA] CTD PMID:31150632 thioacetamide decreases expression ISO RGD:1303107 6480464 Thioacetamide results in decreased expression of VKORC1 mRNA CTD PMID:23411599 valproic acid increases expression ISO RGD:1332416 6480464 Valproic Acid results in increased expression of VKORC1 mRNA CTD PMID:21427059 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of VKORC1 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VKORC1 mRNA CTD PMID:27188386 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of VKORC1 mRNA CTD PMID:25979313 vitamin E multiple interactions EXP 6480464 [Selenium co-treated with Vitamin E] results in increased expression of VKORC1 mRNA CTD PMID:19244175 vitamin E increases expression EXP 6480464 Vitamin E results in increased expression of VKORC1 mRNA CTD PMID:19244175 vitamin K epoxide multiple interactions EXP 6480464 [VKORC1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein more ... CTD PMID:23928358 , PMID:29581108 vitamin K epoxide multiple interactions ISO RGD:1303107 6480464 Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide] CTD PMID:23928358 vitamin K epoxide affects reduction ISO RGD:1303107 6480464 VKORC1 protein affects the reduction of vitamin K1 oxide CTD PMID:23928358 vitamin K epoxide increases reduction EXP 6480464 VKORC1 protein results in increased reduction of vitamin K1 oxide CTD PMID:23928358 , PMID:29581108 warfarin affects response to substance EXP 6480464 VKORC1 affects the susceptibility to Warfarin more ... CTD PMID:15358623 more ... warfarin decreases activity ISO RGD:1303107 6480464 Warfarin results in decreased activity of VKORC1 protein CTD PMID:17941040 warfarin decreases response to substance ISO RGD:1303107 6480464 VKORC1 gene mutant form results in decreased susceptibility to Warfarin, VKORC1 protein polymorphism results in decreased susceptibility to Warfarin CTD PMID:14765194 more ... warfarin affects response to substance ISO RGD:1303107 6480464 VKORC1 protein mutant form affects the susceptibility to Warfarin CTD PMID:23018795 warfarin decreases activity EXP 6480464 Warfarin results in decreased activity of VKORC1 protein CTD PMID:14765194 more ... warfarin decreases response to substance ISO RGD:1332416 6480464 VKORC1 gene mutant form results in decreased susceptibility to Warfarin, VKORC1 protein polymorphism results in decreased susceptibility to Warfarin CTD PMID:19200363 , PMID:27117082 warfarin decreases metabolic processing EXP 6480464 VKORC1 gene polymorphism results in decreased metabolism of Warfarin CTD PMID:20073138 warfarin multiple interactions ISO RGD:1303107 6480464 Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide] CTD PMID:23928358 warfarin affects metabolic processing EXP 6480464 VKORC1 protein affects the metabolism of Warfarin CTD PMID:20073138 warfarin increases response to substance EXP 6480464 VKORC1 intron polymorphism results in increased susceptibility to Warfarin more ... CTD PMID:16676068 more ... warfarin multiple interactions EXP 6480464 [CYP4F2 gene polymorphism co-treated with VKORC1 gene mutant form] affects the susceptibility to Warfarin more ... CTD PMID:21084764 more ... warfarin affects abundance EXP 6480464 VKORC1 gene polymorphism affects the abundance of Warfarin CTD PMID:25986145 warfarin decreases response to substance EXP 6480464 VKORC1 3' UTR results in decreased susceptibility to Warfarin more ... CTD PMID:14765194 more ...
Gene-Chemical Interaction Annotations
