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Gene: VKORC1 (vitamin K epoxide reductase complex subunit 1) Homo sapiens
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Symbol: VKORC1
Name: vitamin K epoxide reductase complex subunit 1
Description: Exhibits vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in several processes, including blood coagulation; peptidyl-glutamic acid carboxylation; and vitamin K metabolic process. Localizes to the endoplasmic reticulum. Implicated in inherited blood coagulation disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EDTP308; FLJ00289; IMAGE3455200; MGC2694; MST134; MST576; phylloquinone epoxide reductase; vitamin K dependent clotting factors deficiency 2; vitamin K epoxide reductase complex, subunit 1; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); VKCFD2; VKOR
Orthologs:
Mus musculus (house mouse) : Vkorc1 (vitamin K epoxide reductase complex, subunit 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vkorc1 (vitamin K epoxide reductase complex, subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vkorc1 (vitamin K epoxide reductase complex subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : VKORC1 (vitamin K epoxide reductase complex subunit 1)
Canis lupus familiaris (dog) : VKORC1 (vitamin K epoxide reductase complex subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vkorc1 (vitamin K epoxide reductase complex subunit 1)
Sus scrofa (pig) : VKORC1 (vitamin K epoxide reductase complex subunit 1)
more info ...
Related Pseudogenes: VKORC1P1   VKORC1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,090,842 - 31,094,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371631,102,175 - 31,106,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,009,676 - 31,013,777 (-)NCBINCBI36hg18NCBI36
Celera1629,191,224 - 29,195,328 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,663,874 - 28,667,978 (-)NCBIHuRef
CHM1_11632,419,464 - 32,423,640 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on VKORC1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604306
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.