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Gene: AMBRA1 (autophagy and beclin 1 regulator 1) Homo sapiens
Symbol: AMBRA1
Name: autophagy and beclin 1 regulator 1
Description: Exhibits GTPase binding activity and ubiquitin protein ligase binding activity. Involved in macroautophagy; positive regulation of phosphatidylinositol 3-kinase activity; and response to mitochondrial depolarisation. Localizes to the cytosol and mitochondrion. Biomarker of multiple system atrophy; PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; mitochondrial autophagy pathway; INTERACTS WITH arsane; arsenic atom; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activating molecule in beclin-1-regulated autophagy; activating molecule in BECN1-regulated autophagy protein 1; autophagy/beclin-1 regulator 1; DCAF3; DDB1 and CUL4 associated factor 3; FLJ20294; KIAA1736; MGC33725; WD repeat domain 94; WDR94
Mus musculus (house mouse) : Ambra1 (autophagy/beclin 1 regulator 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ambra1 (autophagy and beclin 1 regulator 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ambra1 (autophagy and beclin 1 regulator 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AMBRA1 (autophagy and beclin 1 regulator 1)
Canis lupus familiaris (dog) : AMBRA1 (autophagy and beclin 1 regulator 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ambra1 (autophagy and beclin 1 regulator 1)
Sus scrofa (pig) : AMBRA1 (autophagy and beclin 1 regulator 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1146,396,414 - 46,594,125 (-)Ensembl
GRCh381146,396,412 - 46,594,055 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371146,417,962 - 46,615,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,374,541 - 46,569,490 (-)NCBINCBI36hg18NCBI36
Celera1146,566,035 - 46,760,894 (-)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,124,697 - 46,322,307 (-)NCBIHuRef
CHM1_11146,416,414 - 46,614,031 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AMBRA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604349
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.