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Gene: SORBS3 (sorbin and SH3 domain containing 3) Homo sapiens
Symbol: SORBS3
Name: sorbin and SH3 domain containing 3
Description: Exhibits vinculin binding activity. Involved in positive regulation of stress fiber assembly. Colocalizes with focal adhesion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: SCAM-1; SCAM1; SH3-containing adapter molecule 1; SH3D4; sorbin and SH3 domain-containing protein 3; vinexin; vinexin beta (SH3-containing adaptor molecule-1)
Mus musculus (house mouse) : Sorbs3 (sorbin and SH3 domain containing 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sorbs3 (sorbin and SH3 domain containing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sorbs3 (sorbin and SH3 domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SORBS3 (sorbin and SH3 domain containing 3)
Canis lupus familiaris (dog) : SORBS3 (sorbin and SH3 domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sorbs3 (sorbin and SH3 domain containing 3)
Sus scrofa (pig) : SORBS3 (sorbin and SH3 domain containing 3)
Chlorocebus sabaeus (African green monkey) : SORBS3 (sorbin and SH3 domain containing 3)
Heterocephalus glaber (naked mole-rat) : Sorbs3 (sorbin and SH3 domain containing 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl822,544,986 - 22,575,788 (+)EnsemblGRCh38hg38GRCh38
GRCh38822,544,990 - 22,575,788 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37822,402,228 - 22,433,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,465,196 - 22,488,953 (+)NCBINCBI36hg18NCBI36
Celera821,370,859 - 21,394,614 (+)NCBI
Cytogenetic Map8p21.3NCBI
HuRef820,951,413 - 20,975,170 (+)NCBIHuRef
CHM1_1822,611,605 - 22,635,365 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SORBS3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604395
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.