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Gene: NLRC5 (NLR family CARD domain containing 5) Homo sapiens
Symbol: NLRC5
Name: NLR family CARD domain containing 5
CRRD ID: 1604572
Description: Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism; regulation of cytokine-mediated signaling pathway; and regulation of macromolecule biosynthetic process. Localizes to centrosome; cytosol; and nucleus. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: caterpiller protein 16.1; CLR16.1; FLJ21709; FLJ39711; NLR family, CARD domain containing 5; NOD-like receptor C5; NOD27; NOD4; nucleotide-binding oligomerization domain protein 27; nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27
Mus musculus (house mouse) : Nlrc5 (NLR family, CARD domain containing 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nlrc5 (NLR family, CARD domain containing 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrc5 (NLR family CARD domain containing 5)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRC5 (NLR family CARD domain containing 5)
Canis lupus familiaris (dog) : NLRC5 (NLR family CARD domain containing 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrc5 (NLR family CARD domain containing 5)
Sus scrofa (pig) : NLRC5 (NLR family CARD domain containing 5)
Chlorocebus sabaeus (African green monkey) : NLRC5 (NLR family CARD domain containing 5)
Heterocephalus glaber (naked mole-rat) : Nlrc5 (NLR family CARD domain containing 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1656,989,485 - 57,083,531 (+)EnsemblGRCh38hg38GRCh38
GRCh381656,989,557 - 57,083,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371657,023,469 - 57,117,438 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,580,911 - 55,674,937 (+)NCBINCBI36hg18NCBI36
Celera1641,523,685 - 41,617,251 (+)NCBI
Cytogenetic Map16q13NCBI
HuRef1642,920,360 - 42,987,302 (+)NCBIHuRef
CHM1_11658,458,904 - 58,524,899 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NLRC5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604572
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.