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Gene: CD40 (CD40 molecule) Homo sapiens
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Symbol: CD40
Name: CD40 molecule
Description: Exhibits ubiquitin protein ligase binding activity. Involved in several processes, including CD40 signaling pathway; positive regulation of signal transduction; and regulation of transcription, DNA-templated. Localizes to the cell surface and extracellular exosome. Implicated in several diseases, including Kawasaki disease; arthritis (multiple); autoimmune hypersensitivity disease (multiple); hematologic cancer (multiple); and hyperimmunoglobulin syndrome (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); bronchial disease (multiple); hematologic cancer (multiple); and inflammatory bowel disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD40 antigen (TNF receptor superfamily member 5); CD40 molecule TNF receptor superfamily member 5; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40L receptor; CDW40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Orthologs:
Mus musculus (house mouse) : Cd40 (CD40 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd40 (CD40 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd40 (CD40 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD40 (CD40 molecule)
Canis lupus familiaris (dog) : CD40 (CD40 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd40 (CD40 molecule)
Sus scrofa (pig) : CD40 (CD40 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382046,118,242 - 46,129,858 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372044,746,899 - 44,758,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,180,313 - 44,191,791 (+)NCBINCBI36hg18NCBI36
Celera2041,458,363 - 41,469,842 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2041,488,189 - 41,499,674 (+)NCBIHuRef
CHM1_12044,649,527 - 44,661,003 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CD40
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604657
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.