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Gene: CD86 (CD86 molecule) Homo sapiens
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Symbol: CD86
Name: CD86 molecule
CRRD ID: 1604658
Description: Predicted to have signaling receptor activity. Predicted to be involved in several processes, including CD40 signaling pathway; activation of phospholipase C activity; and regulation of T cell activation. Localizes to extracellular exosome. Implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Biomarker of several diseases, including autoimmune disease (multiple); cryoglobulinemia; hematologic cancer (multiple); lung disease (multiple); and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activation B7-2 antigen; B-lymphocyte activation antigen B7-2; B-lymphocyte antigen B7-2; B7-2; B7-2 antigen; B7.2; B70; BU63; CD28 antigen ligand 2; CD28LG2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CTLA-4 counter-receptor B7.2; FUN-1; LAB72; MGC34413; T-lymphocyte activation antigen CD86
Orthologs:
Mus musculus (house mouse) : Cd86 (CD86 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd86 (CD86 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd86 (CD86 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD86 (CD86 molecule)
Canis lupus familiaris (dog) : CD86 (CD86 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd86 (CD86 molecule)
Sus scrofa (pig) : CD86 (CD86 molecule)
Chlorocebus sabaeus (African green monkey) : CD86 (CD86 molecule)
Heterocephalus glaber (naked mole-rat) : Cd86 (CD86 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3122,055,362 - 122,121,139 (+)EnsemblGRCh38hg38GRCh38
GRCh383122,055,362 - 122,121,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373121,774,209 - 121,839,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,256,911 - 123,322,673 (+)NCBINCBI36hg18NCBI36
Celera3120,183,894 - 120,249,657 (+)NCBI
Cytogenetic Map3q13.33NCBI
HuRef3119,148,000 - 119,213,630 (+)NCBIHuRef
CHM1_13121,738,233 - 121,803,970 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CD86
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604658
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.