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Gene: CD86 (CD86 molecule) Homo sapiens
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Symbol: CD86
Name: CD86 molecule
Description: Predicted to have signaling receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; cellular response to lipopolysaccharide; and regulation of T cell activation. Localizes to the extracellular exosome. Implicated in several diseases, including Henoch-Schoenlein purpura; asthma; autoimmune hypersensitivity disease (multiple); chronic lymphocytic leukemia; and chronic obstructive pulmonary disease. Biomarker of several diseases, including autoimmune thrombocytopenic purpura; cryoglobulinemia; hematologic cancer (multiple); lung disease (multiple); and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activation B7-2 antigen; B-lymphocyte activation antigen B7-2; B-lymphocyte antigen B7-2; B7-2; B7-2 antigen; B7.2; B70; BU63; CD28 antigen ligand 2; CD28LG2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CTLA-4 counter-receptor B7.2; FUN-1; LAB72; MGC34413; T-lymphocyte activation antigen CD86
Orthologs:
Mus musculus (house mouse) : Cd86 (CD86 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd86 (CD86 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd86 (CD86 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD86 (CD86 molecule)
Canis lupus familiaris (dog) : CD86 (CD86 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd86 (CD86 molecule)
Sus scrofa (pig) : CD86 (CD86 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,055,362 - 122,121,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373121,774,209 - 121,839,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,256,911 - 123,322,673 (+)NCBINCBI36hg18NCBI36
Celera3120,183,894 - 120,249,657 (+)NCBI
Cytogenetic Map3q13.33NCBI
HuRef3119,148,000 - 119,213,630 (+)NCBIHuRef
CHM1_13121,738,233 - 121,803,970 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CD86
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604658
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.