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Gene: ATG4A (autophagy related 4A cysteine peptidase) Homo sapiens
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Symbol: ATG4A
Name: autophagy related 4A cysteine peptidase
Description: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APG4 autophagy 4 homolog A; APG4A; ATG4 autophagy related 4 homolog A; AUT-like 2 cysteine endopeptidase; AUT-like 2, cysteine endopeptidase; AUTL2; autophagin 2; autophagin-2; autophagy related 4A, cysteine peptidase; autophagy-related cysteine endopeptidase 2; autophagy-related protein 4 homolog A; cysteine protease ATG4A; hAPG4A
Orthologs:
Mus musculus (house mouse) : Atg4a (autophagy related 4A, cysteine peptidase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atg4a (autophagy related 4A, cysteine peptidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atg4a (autophagy related 4A cysteine peptidase)
Pan paniscus (bonobo/pygmy chimpanzee) : ATG4A (autophagy related 4A cysteine peptidase)
Canis lupus familiaris (dog) : ATG4A (autophagy related 4A cysteine peptidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atg4a (autophagy related 4A cysteine peptidase)
Sus scrofa (pig) : ATG4A (autophagy related 4A cysteine peptidase)
more info ...
Related Pseudogenes: ATG4AP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X108,091,667 - 108,154,671 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X107,334,899 - 107,397,901 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X107,221,590 - 107,284,552 (+)NCBINCBI36hg18NCBI36
CeleraX107,806,406 - 107,869,363 (+)NCBI
Cytogenetic MapXq22.3NCBI
HuRefX96,957,585 - 97,020,331 (+)NCBIHuRef
CHM1_1X107,245,773 - 107,308,734 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ATG4A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604759
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.