Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SIGIRR (single Ig and TIR domain containing) Homo sapiens
Symbol: SIGIRR
Name: single Ig and TIR domain containing
Description: Involved in negative regulation of DNA-binding transcription factor activity. Localizes to membrane; PARTICIPATES IN interleukin-1 signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IL-1R8; interleukin-1 receptor 8 long isoform; MGC110992; single Ig IL-1-related receptor; single Ig IL-1R-related molecule; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; TIR8; toll/interleukin-1 receptor 8
Mus musculus (house mouse) : Sigirr (single immunoglobulin and toll-interleukin 1 receptor (TIR) domain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sigirr (single Ig and TIR domain containing)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sigirr (single Ig and TIR domain containing)
Pan paniscus (bonobo/pygmy chimpanzee) : SIGIRR (single Ig and TIR domain containing)
Canis lupus familiaris (dog) : SIGIRR (single Ig and TIR domain containing)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sigirr (single Ig and TIR domain containing)
Sus scrofa (pig) : SIGIRR (single Ig and TIR domain containing)
Chlorocebus sabaeus (African green monkey) : SIGIRR (single Ig and TIR domain containing)
Heterocephalus glaber (naked mole-rat) : Sigirr (single Ig and TIR domain containing)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11405,716 - 417,455 (-)EnsemblGRCh38hg38GRCh38
GRCh3811405,716 - 417,454 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711405,716 - 417,454 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611395,716 - 407,397 (-)NCBINCBI36hg18NCBI36
Cytogenetic Map11p15.5NCBI
HuRef11220,437 - 232,467 (-)NCBIHuRef
CHM1_111404,638 - 415,857 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIGIRR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604804
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.