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Gene: TP63 (tumor protein p63) Homo sapiens
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Symbol: TP63
Name: tumor protein p63
CRRD ID: 1604844
Description: Exhibits several functions, including MDM2/MDM4 family protein binding activity; WW domain binding activity; and p53 binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of fibroblast apoptotic process; and regulation of transcription, DNA-templated. Localizes to cytoplasm; nuclear chromatin; and nucleoplasm. Implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Biomarker of cervix uteri carcinoma in situ; prostate carcinoma in situ; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AIS; amplified in squamous cell carcinoma; B(p51A); B(p51B); chronic ulcerative stomatitis protein; CUSP; EEC3; keratinocyte transcription factor KET; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L; transformation-related protein 63; tumor protein 63; tumor protein p53-competing protein; tumor protein p53-like; tumor protein p63 deltaN isoform delta; tumor protein p73-like
Orthologs:
Mus musculus (house mouse) : Trp63 (transformation related protein 63)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tp63 (tumor protein p63)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp63 (tumor protein p63)
Pan paniscus (bonobo/pygmy chimpanzee) : TP63 (tumor protein p63)
Canis lupus familiaris (dog) : TP63 (tumor protein p63)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp63 (tumor protein p63)
Sus scrofa (pig) : TP63 (tumor protein p63)
Chlorocebus sabaeus (African green monkey) : TP63 (tumor protein p63)
Heterocephalus glaber (naked mole-rat) : Tp63 (tumor protein p63)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3189,631,389 - 189,897,276 (+)EnsemblGRCh38hg38GRCh38
GRCh383189,596,746 - 189,897,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373189,348,942 - 189,615,068 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363190,831,910 - 191,097,759 (+)NCBINCBI36hg18NCBI36
Celera3187,783,803 - 188,042,610 (+)NCBI
Cytogenetic Map3q28NCBI
HuRef3186,752,882 - 187,012,887 (+)NCBIHuRef
CHM1_13189,312,090 - 189,577,623 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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