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Gene: UBA1 (ubiquitin like modifier activating enzyme 1) Homo sapiens
Symbol: UBA1
Name: ubiquitin like modifier activating enzyme 1
Description: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A1S9; A1S9T; A1S9T and BN75 temperature sensitivity complementing; A1ST; AMCX1; CFAP124; GXP1; MGC4781; POC20; POC20 centriolar protein homolog; SMAX2; testicular secretory protein Li 63; UBA1, ubiquitin-activating enzyme E1 homolog A; UBA1A; UBE1; UBE1X; ubiquitin-like modifier activating enzyme 1; ubiquitin-like modifier-activating enzyme 1
Mus musculus (house mouse) : Uba1 (ubiquitin-like modifier activating enzyme 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Uba1 (ubiquitin-like modifier activating enzyme 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uba1 (ubiquitin like modifier activating enzyme 1)
Pan paniscus (bonobo/pygmy chimpanzee) : UBA1 (ubiquitin like modifier activating enzyme 1)
Canis lupus familiaris (dog) : UBA1 (ubiquitin like modifier activating enzyme 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uba1 (ubiquitin like modifier activating enzyme 1)
Sus scrofa (pig) : UBA1 (ubiquitin like modifier activating enzyme 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X47,190,847 - 47,215,128 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X47,050,199 - 47,074,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,935,204 - 46,959,471 (+)NCBINCBI36hg18NCBI36
CeleraX51,245,489 - 51,269,819 (+)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX44,761,319 - 44,784,789 (+)NCBIHuRef
CHM1_1X47,081,686 - 47,106,022 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on UBA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604847
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.