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Gene: UBA1 (ubiquitin like modifier activating enzyme 1) Homo sapiens
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Symbol: UBA1
Name: ubiquitin like modifier activating enzyme 1
Description: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A1S9; A1S9T; A1S9T and BN75 temperature sensitivity complementing; A1ST; AMCX1; CFAP124; GXP1; MGC4781; POC20; POC20 centriolar protein homolog; SMAX2; testicular secretory protein Li 63; UBA1, ubiquitin-activating enzyme E1 homolog A; UBA1A; UBE1; UBE1X; ubiquitin-like modifier activating enzyme 1; ubiquitin-like modifier-activating enzyme 1
Orthologs:
Mus musculus (house mouse) : Uba1 (ubiquitin-like modifier activating enzyme 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Uba1 (ubiquitin-like modifier activating enzyme 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uba1 (ubiquitin like modifier activating enzyme 1)
Pan paniscus (bonobo/pygmy chimpanzee) : UBA1 (ubiquitin like modifier activating enzyme 1)
Canis lupus familiaris (dog) : UBA1 (ubiquitin like modifier activating enzyme 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uba1 (ubiquitin like modifier activating enzyme 1)
Sus scrofa (pig) : UBA1 (ubiquitin like modifier activating enzyme 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,190,847 - 47,215,128 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X47,050,199 - 47,074,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,935,204 - 46,959,471 (+)NCBINCBI36hg18NCBI36
CeleraX51,245,489 - 51,269,819 (+)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX44,761,319 - 44,784,789 (+)NCBIHuRef
CHM1_1X47,081,686 - 47,106,022 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on UBA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604847
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.