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Gene: CASP2 (caspase 2) Homo sapiens
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Symbol: CASP2
Name: caspase 2
Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CASP-2; caspase 2 apoptosis-related cysteine peptidase; caspase-2; ICH-1 protease; ICH-1L; ICH-1L/1S; ICH-1S; ICH1; NEDD-2; NEDD2; NEDD2 apoptosis regulatory; neural precursor cell expressed developmentally down-regulated protein 2; neural precursor cell expressed, developmentally down-regulated 2; PPP1R57; protease ICH-1; protein phosphatase 1, regulatory subunit 57
Orthologs:
Mus musculus (house mouse) : Casp2 (caspase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp2 (caspase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp2 (caspase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP2 (caspase 2)
Canis lupus familiaris (dog) : CASP2 (caspase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp2 (caspase 2)
Sus scrofa (pig) : CASP2 (caspase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,288,215 - 143,307,696 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377142,985,308 - 143,004,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,695,524 - 142,714,907 (+)NCBINCBI36hg18NCBI36
Celera7137,822,267 - 137,841,650 (+)NCBI
Cytogenetic Map7q34NCBI
HuRef7137,322,670 - 137,342,153 (+)NCBIHuRef
CHM1_17142,922,195 - 142,941,676 (+)NCBICHM1_1
CRA_TCAGchr7v27142,387,424 - 142,406,906 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CASP2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604850
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.