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Gene: CASP2 (caspase 2) Homo sapiens
Symbol: CASP2
Name: caspase 2
Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CASP-2; caspase 2 apoptosis-related cysteine peptidase; caspase-2; ICH-1 protease; ICH-1L; ICH-1L/1S; ICH-1S; ICH1; NEDD-2; NEDD2; NEDD2 apoptosis regulatory; neural precursor cell expressed developmentally down-regulated protein 2; neural precursor cell expressed, developmentally down-regulated 2; PPP1R57; protease ICH-1; protein phosphatase 1, regulatory subunit 57
Mus musculus (house mouse) : Casp2 (caspase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp2 (caspase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp2 (caspase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP2 (caspase 2)
Canis lupus familiaris (dog) : CASP2 (caspase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp2 (caspase 2)
Sus scrofa (pig) : CASP2 (caspase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387143,288,215 - 143,307,696 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377142,985,308 - 143,004,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,695,524 - 142,714,907 (+)NCBINCBI36hg18NCBI36
Celera7137,822,267 - 137,841,650 (+)NCBI
Cytogenetic Map7q34NCBI
HuRef7137,322,670 - 137,342,153 (+)NCBIHuRef
CHM1_17142,922,195 - 142,941,676 (+)NCBICHM1_1
CRA_TCAGchr7v27142,387,424 - 142,406,906 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CASP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1604850
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.