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Gene: SPPL3 (signal peptide peptidase like 3) Homo sapiens
Symbol: SPPL3
Name: signal peptide peptidase like 3
CRRD ID: 1605007
Description: Exhibits aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein dephosphorylation. Localizes to several cellular components, including Golgi-associated vesicle membrane; integral component of endoplasmic reticulum membrane; and rough endoplasmic reticulum; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; benzo[a]pyrene diol epoxide I; benzo[e]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp586C1324; IMP-2; IMP2; intramembrane protease 2; MDHV1887; MGC126674; MGC126676; MGC90402; presenilin homologous protein 1; presenilin-like protein 4; PRO4332; PSH1; PSL4; signal peptide peptidase-like 3; SPP-like 3
Mus musculus (house mouse) : Sppl3 (signal peptide peptidase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sppl3 (signal peptide peptidase like 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sppl3 (signal peptide peptidase like 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SPPL3 (signal peptide peptidase like 3)
Canis lupus familiaris (dog) : SPPL3 (signal peptide peptidase like 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sppl3 (signal peptide peptidase like 3)
Sus scrofa (pig) : SPPL3 (signal peptide peptidase like 3)
Chlorocebus sabaeus (African green monkey) : SPPL3 (signal peptide peptidase like 3)
Heterocephalus glaber (naked mole-rat) : Sppl3 (signal peptide peptidase like 3)
more info ...
Related Pseudogenes: AC091691.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl12120,762,510 - 120,904,358 (-)EnsemblGRCh38hg38GRCh38
GRCh3812120,762,510 - 120,904,358 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712121,200,313 - 121,342,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,685,418 - 119,826,534 (-)NCBINCBI36hg18NCBI36
Celera12120,835,168 - 120,976,050 (-)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12118,209,451 - 118,351,576 (-)NCBIHuRef
CHM1_112121,169,084 - 121,310,844 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPPL3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605007
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.