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Gene: KEAP1 (kelch like ECH associated protein 1) Homo sapiens
Symbol: KEAP1
Name: kelch like ECH associated protein 1
Description: Exhibits transcription factor binding activity. Involved in cellular protein metabolic process; cellular response to oxidative stress; and regulation of autophagy. Localizes to several cellular components, including Cul3-RING ubiquitin ligase complex; centriolar satellite; and midbody. Implicated in gallbladder cancer. Biomarker of amyotrophic lateral sclerosis; idiopathic interstitial pneumonia; and pulmonary emphysema.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytosolic inhibitor of Nrf2; INrf2; KEAP1 delta C; kelch-like ECH-associated protein 1; kelch-like family member 19; kelch-like protein 19; KIAA0132; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454
Mus musculus (house mouse) : Keap1 (kelch-like ECH-associated protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Keap1 (Kelch-like ECH-associated protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Keap1 (kelch like ECH associated protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KEAP1 (kelch like ECH associated protein 1)
Canis lupus familiaris (dog) : KEAP1 (kelch like ECH associated protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Keap1 (kelch like ECH associated protein 1)
Sus scrofa (pig) : KEAP1 (kelch like ECH associated protein 1)
Chlorocebus sabaeus (African green monkey) : KEAP1 (kelch like ECH associated protein 1)
Heterocephalus glaber (naked mole-rat) : Keap1 (kelch like ECH associated protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1910,486,125 - 10,503,558 (-)EnsemblGRCh38hg38GRCh38
GRCh381910,486,125 - 10,503,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,596,796 - 10,614,054 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,457,796 - 10,475,054 (-)NCBINCBI36hg18NCBI36
Celera1910,491,509 - 10,508,764 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,176,101 - 10,192,927 (-)NCBIHuRef
CHM1_11910,597,575 - 10,614,823 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KEAP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605110
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.