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Gene: ERN1 (endoplasmic reticulum to nucleus signaling 1) Homo sapiens
Symbol: ERN1
Name: endoplasmic reticulum to nucleus signaling 1
Description: Exhibits several functions, including adenyl ribonucleotide binding activity; heat shock protein binding activity; and magnesium ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; mRNA processing; and protein phosphorylation. Localizes to the IRE1-RACK1-PP2A complex; endoplasmic reticulum; and endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: endoplasmic reticulum-to-nucleus signaling 1; ER to nucleus signalling 1; FLJ30999; hIRE1p; inositol-requiring 1; inositol-requiring enzyme 1; inositol-requiring protein 1; IRE1; ire1-alpha; IRE1a; IRE1P; MGC163277; MGC163279; protein kinase/endoribonuclease; serine/threonine-protein kinase/endoribonuclease IRE1
Mus musculus (house mouse) : Ern1 (endoplasmic reticulum (ER) to nucleus signalling 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ern1 (endoplasmic reticulum to nucleus signaling 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Canis lupus familiaris (dog) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
Sus scrofa (pig) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Chlorocebus sabaeus (African green monkey) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Heterocephalus glaber (naked mole-rat) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1764,039,142 - 64,130,819 (-)Ensembl
GRCh381764,039,142 - 64,132,469 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371762,116,502 - 62,207,502 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,474,122 - 59,561,234 (-)NCBINCBI36hg18NCBI36
Celera1756,508,473 - 56,595,582 (-)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1757,488,466 - 57,575,481 (-)NCBIHuRef
CHM1_11762,184,805 - 62,271,973 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ERN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605125
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.