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Gene: C4B (complement C4B (Chido blood group)) Homo sapiens
Symbol: C4B
Name: complement C4B (Chido blood group)
Description: Exhibits carbohydrate binding activity and complement component C1q binding activity. Involved in complement activation; detection of molecule of bacterial origin; and positive regulation of apoptotic cell clearance. Localizes to several cellular components, including the dendrite; neuronal cell body; and other organism cell. Implicated in autistic disorder; autoimmune hypersensitivity disease (multiple); complement component 4b deficiency; renal cell carcinoma; and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic C4; basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; C4B1; C4B12; C4B2; C4B3; C4B5; C4B_2; C4BD; C4F; CH; Chido form of C4; CO4; complement C4-B; complement C4B1a; complement component 4B (Chido blood group); CPAMD3; FLJ60561; MGC164979
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38632,014,795 - 32,035,418 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,982,572 - 32,003,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,057,813 - 32,078,435 (+)NCBINCBI36hg18NCBI36
Celera633,549,596 - 33,570,219 (+)NCBI
Cytogenetic Map6p21.33NCBI
CHM1_1631,984,848 - 32,005,386 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on C4B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605129
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.