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Gene: PEF1 (penta-EF-hand domain containing 1) Homo sapiens
Symbol: PEF1
Name: penta-EF-hand domain containing 1
Description: Exhibits calcium-dependent protein binding activity; protein binding activity, bridging involved in substrate recognition for ubiquitination; and protein heterodimerization activity. Involved in several processes, including COPII vesicle coating; mesenchymal cell differentiation; and positive regulation of protein monoubiquitination. Localizes to the COPII vesicle coat and Cul3-RING ubiquitin ligase complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABP32; PEF protein with a long N-terminal hydrophobic domain; PEF1A; peflin; penta-EF hand domain containing 1; penta-EF hand domain-containing protein 1
Mus musculus (house mouse) : Pef1 (penta-EF hand domain containing 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pef1 (penta-EF hand domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pef1 (penta-EF-hand domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PEF1 (penta-EF-hand domain containing 1)
Canis lupus familiaris (dog) : PEF1 (penta-EF-hand domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pef1 (penta-EF-hand domain containing 1)
Sus scrofa (pig) : PEF1 (penta-EF-hand domain containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38131,629,862 - 31,644,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37132,095,463 - 32,110,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36131,868,058 - 31,883,064 (-)NCBINCBI36hg18NCBI36
Celera130,364,685 - 30,380,064 (-)NCBI
Cytogenetic Map1p35.2NCBI
HuRef130,212,972 - 30,228,346 (-)NCBIHuRef
CHM1_1132,211,259 - 32,226,634 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PEF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605152
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.