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Gene: HIF3A (hypoxia inducible factor 3 subunit alpha) Homo sapiens
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Symbol: HIF3A
Name: hypoxia inducible factor 3 subunit alpha
Description: The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic-helix-loop-helix-PAS protein MOP7; bHLHe17; class E basic helix-loop-helix protein 17; HIF-3-alpha; HIF-3A; HIF-3A2; HIF-3A4; HIF3-alpha; HIF3-alpha-1; hypoxia inducible factor 3 alpha subunit; hypoxia inducible factor 3, alpha subunit; hypoxia-inducible factor 3-alpha; hypoxia-inducible factor-3 alpha 4; inhibitory PAS domain protein; IPAS; member of PAS protein 7; MOP7; PAS domain-containing protein 7; PASD7
Orthologs:
Mus musculus (house mouse) : Hif3a (hypoxia inducible factor 3, alpha subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hif3a (hypoxia inducible factor 3 subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hif3a (hypoxia inducible factor 3 subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : HIF3A (hypoxia inducible factor 3 subunit alpha)
Canis lupus familiaris (dog) : HIF3A (hypoxia inducible factor 3 subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hif3a (hypoxia inducible factor 3 subunit alpha)
Sus scrofa (pig) : HIF3A (hypoxia inducible factor 3 subunit alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,297,042 - 46,343,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371946,800,303 - 46,846,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,492,145 - 51,538,530 (+)NCBINCBI36hg18NCBI36
Celera1943,605,284 - 43,651,680 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1943,228,311 - 43,274,715 (+)NCBIHuRef
CHM1_11946,802,171 - 46,848,539 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HIF3A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605351
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.