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Gene: HIF3A (hypoxia inducible factor 3 subunit alpha) Homo sapiens
Symbol: HIF3A
Name: hypoxia inducible factor 3 subunit alpha
Description: The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic-helix-loop-helix-PAS protein MOP7; bHLHe17; class E basic helix-loop-helix protein 17; HIF-3-alpha; HIF-3A; HIF-3A2; HIF-3A4; HIF3-alpha; HIF3-alpha-1; hypoxia inducible factor 3 alpha subunit; hypoxia inducible factor 3, alpha subunit; hypoxia-inducible factor 3-alpha; hypoxia-inducible factor-3 alpha 4; inhibitory PAS domain protein; IPAS; member of PAS protein 7; MOP7; PAS domain-containing protein 7; PASD7
Mus musculus (house mouse) : Hif3a (hypoxia inducible factor 3, alpha subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hif3a (hypoxia inducible factor 3 subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hif3a (hypoxia inducible factor 3 subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : HIF3A (hypoxia inducible factor 3 subunit alpha)
Canis lupus familiaris (dog) : HIF3A (hypoxia inducible factor 3 subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hif3a (hypoxia inducible factor 3 subunit alpha)
Sus scrofa (pig) : HIF3A (hypoxia inducible factor 3 subunit alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381946,297,042 - 46,343,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371946,800,303 - 46,846,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,492,145 - 51,538,530 (+)NCBINCBI36hg18NCBI36
Celera1943,605,284 - 43,651,680 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1943,228,311 - 43,274,715 (+)NCBIHuRef
CHM1_11946,802,171 - 46,848,539 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HIF3A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605351
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.