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Gene: TLR8 (toll like receptor 8) Homo sapiens
Symbol: TLR8
Name: toll like receptor 8
CRRD ID: 1605396
Description: Exhibits identical protein binding activity and nucleic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of interleukin-12 production; and positive regulation of cytokine production. Localizes to external side of plasma membrane. Biomarker of respiratory syncytial virus infectious disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD288; MGC119599; MGC119600; toll-like receptor 8
Mus musculus (house mouse) : Tlr8 (toll-like receptor 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr8 (toll-like receptor 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr8 (toll like receptor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR8 (toll like receptor 8)
Canis lupus familiaris (dog) : TLR8 (toll like receptor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr8 (toll like receptor 8)
Sus scrofa (pig) : TLR8 (toll like receptor 8)
Chlorocebus sabaeus (African green monkey) : TLR8 (toll like receptor 8)
Heterocephalus glaber (naked mole-rat) : Tlr8 (toll like receptor 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX12,906,620 - 12,923,169 (+)EnsemblGRCh38hg38GRCh38
GRCh38X12,906,620 - 12,923,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X12,924,739 - 12,941,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,834,679 - 12,851,209 (+)NCBINCBI36hg18NCBI36
CeleraX17,038,744 - 17,055,292 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX10,691,356 - 10,708,478 (+)NCBIHuRef
CHM1_1X12,955,183 - 12,971,731 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TLR8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605396
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.