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Gene: TPPP (tubulin polymerization promoting protein) Homo sapiens
Symbol: TPPP
Name: tubulin polymerization promoting protein
Description: Exhibits several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Localizes to several cellular components, including the mitochondrion; mitotic spindle; and perinuclear region of cytoplasm. Colocalizes with the microtubule and microtubule bundle; INTERACTS WITH 17beta-estradiol; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 25 kDa brain-specific protein; brain specific protein p25 alpha; glycogen synthase kinase 3 (GSK3) inhibitor p24; p24; p25; p25-alpha; p25alpha; TPPP/p25; TPPP1; tubulin polymerization-promoting protein
Mus musculus (house mouse) : Tppp (tubulin polymerization promoting protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tppp (tubulin polymerization promoting protein)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : TPPP (tubulin polymerization promoting protein)
Canis lupus familiaris (dog) : TPPP (tubulin polymerization promoting protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tppp (tubulin polymerization promoting protein)
Sus scrofa (pig) : TPPP (tubulin polymerization promoting protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5659,862 - 693,352 (-)Ensembl
GRCh385659,862 - 700,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375659,977 - 693,510 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365712,977 - 746,510 (-)NCBINCBI36hg18NCBI36
Celera5756,043 - 773,959 (-)NCBI
Cytogenetic Map5p15.33NCBI
HuRef5643,544 - 661,474 (-)NCBIHuRef
CHM1_15655,371 - 689,478 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TPPP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605400
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.