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Gene: KMT2B (lysine methyltransferase 2B) Homo sapiens
Symbol: KMT2B
Name: lysine methyltransferase 2B
Description: Exhibits histone methyltransferase activity (H3-K4 specific); unmethylated CpG binding activity; and zinc ion binding activity. Involved in histone H3-K4 dimethylation and histone H3-K4 monomethylation. Localizes to histone methyltransferase complex. Implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Biomarker of breast cancer and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CXXC10; DYT28; histone-lysine N-methyltransferase 2B; histone-lysine N-methyltransferase MLL4; HRX2; KIAA0304; KMT2D; lysine (K)-specific methyltransferase 2B; lysine N-methyltransferase 2B; lysine N-methyltransferase 2D; mixed lineage leukemia gene homolog 2; MLL1B; MLL2; MLL4; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4; myeloid/lymphoid or mixed-lineage leukemia 4; myeloid/lymphoid or mixed-lineage leukemia protein 4; trithorax homolog 2; trithorax homologue 2; TRX2; WBP-7; WBP7; WW domain binding protein 7; WW domain-binding protein 7
Mus musculus (house mouse) : Kmt2b (lysine (K)-specific methyltransferase 2B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kmt2b (lysine methyltransferase 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2b (lysine methyltransferase 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2B (lysine methyltransferase 2B)
Canis lupus familiaris (dog) : KMT2B (lysine methyltransferase 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2b (lysine methyltransferase 2B)
Sus scrofa (pig) : KMT2B (lysine methyltransferase 2B)
Chlorocebus sabaeus (African green monkey) : KMT2B (lysine methyltransferase 2B)
Heterocephalus glaber (naked mole-rat) : Kmt2b (lysine methyltransferase 2B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1935,717,973 - 35,738,878 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1935,718,019 - 35,738,878 (+)EnsemblGRCh38hg38GRCh38
GRCh381935,717,818 - 35,738,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371936,208,921 - 36,229,781 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,900,761 - 40,921,619 (+)NCBINCBI36hg18NCBI36
Celera1932,922,394 - 32,943,254 (+)NCBI
Cytogenetic Map19q13.12NCBI
HuRef1932,713,511 - 32,734,772 (+)NCBIHuRef
CHM1_11936,210,261 - 36,231,103 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KMT2B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605411
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.