Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: RAC1 (Rac family small GTPase 1) Homo sapiens
Analyze
Symbol: RAC1
Name: Rac family small GTPase 1
Description: Exhibits GTP binding activity; GTPase activity; and enzyme binding activity. Involved in several processes, including plasma membrane bounded cell projection assembly; positive regulation of cellular component organization; and positive regulation of neutrophil chemotaxis. Localizes to several cellular components, including the recycling endosome membrane; ruffle membrane; and trans-Golgi network. Colocalizes with the actin filament. Implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Biomarker of colon adenocarcinoma; colon adenoma; colorectal cancer; and pancreatic ductal adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell migration-inducing gene 5 protein; MGC111543; MIG5; migration-inducing gene 5; MRD48; p21-Rac1; Rac-1; ras-like protein TC25; ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1; TC-25
Orthologs:
Mus musculus (house mouse) : Rac1 (Rac family small GTPase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rac1 (Rac family small GTPase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rac1 (Rac family small GTPase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RAC1 (Rac family small GTPase 1)
Canis lupus familiaris (dog) : RAC1 (Rac family small GTPase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rac1 (Rac family small GTPase 1)
Sus scrofa (pig) : RAC1 (Rac family small GTPase 1)
more info ...
Related Pseudogenes: RAC1P1   RAC1P2   RAC1P3   RAC1P4   RAC1P5   RAC1P6   RAC1P7   RAC1P8   RAC1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,374,527 - 6,403,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3776,414,126 - 6,443,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,380,651 - 6,410,123 (+)NCBINCBI36hg18NCBI36
Celera76,291,529 - 6,321,004 (-)NCBI
Cytogenetic Map7p22.1NCBI
HuRef76,287,239 - 6,316,490 (+)NCBIHuRef
CHM1_176,413,683 - 6,443,197 (+)NCBICHM1_1
CRA_TCAGchr7v276,460,486 - 6,489,951 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RAC1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605432
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.