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Gene: HES1 (hes family bHLH transcription factor 1) Homo sapiens
Symbol: HES1
Name: hes family bHLH transcription factor 1
CRRD ID: 1605434
Description: Exhibits histone deacetylase binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of transcription by RNA polymerase II; and neuronal stem cell population maintenance. Localizes to nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHb39; class B basic helix-loop-helix protein 39; FLJ20408; hairy homolog; hairy-like protein; HES-1; HHL; HRY; transcription factor HES-1
Mus musculus (house mouse) : Hes1 (hes family bHLH transcription factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hes1 (hes family bHLH transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hes1 (hes family bHLH transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HES1 (hes family bHLH transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hes1 (hes family bHLH transcription factor 1)
Sus scrofa (pig) : HES1 (hes family bHLH transcription factor 1)
Chlorocebus sabaeus (African green monkey) : HES1 (hes family bHLH transcription factor 1)
Heterocephalus glaber (naked mole-rat) : Hes1 (hes family bHLH transcription factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3194,136,148 - 194,138,732 (+)EnsemblGRCh38hg38GRCh38
GRCh383194,136,148 - 194,138,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373193,853,931 - 193,856,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,336,628 - 195,339,090 (+)NCBINCBI36hg18NCBI36
Celera3192,270,388 - 192,272,854 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3191,241,261 - 191,243,734 (+)NCBIHuRef
CHM1_13193,816,827 - 193,819,297 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HES1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605434
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.