Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Homo sapiens
Analyze
Symbol: APPL2
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Description: Exhibits phosphatidylinositol binding activity; phosphatidylserine binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of glucose import; protein homotetramerization; and protein import into nucleus. Localizes to the endosome membrane; nucleus; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13 beta; dip13-beta; DIP13B; FLJ10659
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl12105,173,297 - 105,236,203 (-)EnsemblGRCh38hg38GRCh38
GRCh3812105,173,297 - 105,236,230 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712105,567,075 - 105,630,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,091,205 - 104,154,138 (-)NCBINCBI36hg18NCBI36
Celera12105,231,366 - 105,294,273 (-)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12102,626,453 - 102,689,404 (-)NCBIHuRef
CHM1_112105,532,775 - 105,595,738 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on APPL2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605653
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.