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Gene: CD274 (CD274 molecule) Homo sapiens
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Symbol: CD274
Name: CD274 molecule
Description: Involved in several processes, including negative regulation of cytokine production; positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process; and regulation of T cell activation. Localizes to the endosome membrane; extracellular exosome; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B7 homolog 1; B7-H; B7H1; CD274 antigen; hPD-L1; MGC142294; MGC142296; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; programmed cell death 1 ligand 1; programmed death ligand 1
Orthologs:
Mus musculus (house mouse) : Cd274 (CD274 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd274 (CD274 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd274 (CD274 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD274 (CD274 molecule)
Canis lupus familiaris (dog) : CD274 (CD274 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd274 (CD274 molecule)
Sus scrofa (pig) : CD274 (CD274 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3895,450,503 - 5,470,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3795,450,503 - 5,470,567 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,440,559 - 5,458,477 (+)NCBINCBI36hg18NCBI36
Celera95,376,139 - 5,396,204 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef95,406,210 - 5,426,274 (+)NCBIHuRef
CHM1_195,450,664 - 5,470,759 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CD274
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605684
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.