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Gene: MSL3 (MSL complex subunit 3) Homo sapiens
Symbol: MSL3
Name: MSL complex subunit 3
Description: This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp586J1822; drosophila MSL3-like 1; male-specific lethal 3 homolog; male-specific lethal 3 homolog (Drosophila); male-specific lethal 3-like 1; male-specific lethal-3 homolog 1; male-specific lethal-3 protein-like 1; MSL3-like 1; MSL3L1
Mus musculus (house mouse) : Msl3 (MSL complex subunit 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Msl3 (MSL complex subunit 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msl3 (MSL complex subunit 3)
Pan paniscus (bonobo/pygmy chimpanzee) : MSL3 (MSL complex subunit 3)
Canis lupus familiaris (dog) : MSL3 (MSL complex subunit 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msl3 (MSL complex subunit 3)
Sus scrofa (pig) : MSL3 (MSL complex subunit 3)
more info ...
Related Pseudogenes: MSL3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X11,758,159 - 11,775,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X11,776,278 - 11,793,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X11,686,199 - 11,703,793 (+)NCBINCBI36hg18NCBI36
CeleraX15,904,870 - 15,922,463 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX9,555,123 - 9,572,080 (+)NCBIHuRef
CHM1_1X11,806,915 - 11,824,468 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MSL3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605696
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.