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Gene: MSL3 (MSL complex subunit 3) Homo sapiens
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Symbol: MSL3
Name: MSL complex subunit 3
Description: This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp586J1822; drosophila MSL3-like 1; male-specific lethal 3 homolog; male-specific lethal 3 homolog (Drosophila); male-specific lethal 3-like 1; male-specific lethal-3 homolog 1; male-specific lethal-3 protein-like 1; MSL3-like 1; MSL3L1
Orthologs:
Mus musculus (house mouse) : Msl3 (MSL complex subunit 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Msl3 (MSL complex subunit 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msl3 (MSL complex subunit 3)
Pan paniscus (bonobo/pygmy chimpanzee) : MSL3 (MSL complex subunit 3)
Canis lupus familiaris (dog) : MSL3 (MSL complex subunit 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msl3 (MSL complex subunit 3)
Sus scrofa (pig) : MSL3 (MSL complex subunit 3)
more info ...
Related Pseudogenes: MSL3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X11,758,159 - 11,775,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X11,776,278 - 11,793,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X11,686,199 - 11,703,793 (+)NCBINCBI36hg18NCBI36
CeleraX15,904,870 - 15,922,463 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX9,555,123 - 9,572,080 (+)NCBIHuRef
CHM1_1X11,806,915 - 11,824,468 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MSL3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605696
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.