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Gene: TFAM (transcription factor A, mitochondrial) Homo sapiens
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Symbol: TFAM
Name: transcription factor A, mitochondrial
Description: Exhibits DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in positive regulation of transcription, DNA-templated and transcription initiation from mitochondrial promoter. Localizes to the mitochondrial nucleoid and protein-containing complex. Implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Biomarker of obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: mitochondrial transcription factor 1; mitochondrial transcription factor A; MTDPS15; MtTF1; mtTFA; TCF-6; TCF6; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; Transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3
Orthologs:
Mus musculus (house mouse) : Tfam (transcription factor A, mitochondrial)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tfam (transcription factor A, mitochondrial)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfam (transcription factor A, mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : TFAM (transcription factor A, mitochondrial)
Canis lupus familiaris (dog) : TFAM (transcription factor A, mitochondrial)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfam (transcription factor A, mitochondrial)
Sus scrofa (pig) : TFAM (transcription factor A, mitochondrial)
more info ...
Related Pseudogenes: TFAMP1   TFAMP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381058,385,143 - 58,399,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371060,144,903 - 60,158,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361059,815,182 - 59,825,903 (+)NCBINCBI36hg18NCBI36
Celera1053,410,112 - 53,420,833 (+)NCBI
Cytogenetic Map10q21.1NCBI
HuRef1054,133,767 - 54,148,729 (+)NCBIHuRef
CHM1_11060,426,687 - 60,440,776 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TFAM
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1605718
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.